Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer

Research output: Contribution to journalJournal articleResearchpeer-review

  • Martina Kluth
  • Rami Galal
  • Antje Krohn
  • Weischenfeldt, Joachim Lütken
  • Christina Tsourlakis
  • Lisa Paustian
  • Ramin Ahrary
  • Malik Ahmed
  • Sekander Scherzai
  • Anne Meyer
  • Hüseyin Sirma
  • Jan Korbel
  • Guido Sauter
  • Thorsten Schlomm
  • Ronald Simon
  • Sarah Minner

Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated to ETS genes in 11 prostate cancers. The aim of the present study was to estimate the prevalence of non-ETS gene fusions. We randomly selected 27 of these rearrangements and analyzed them by fluorescence in situ hybridization (FISH) in a tissue microarray format containing 500 prostate cancers. Using break-apart FISH probes for one fusion partner each, we found rearrangements of 13 (48%) of the 27 analyzed genes in 300-400 analyzable cancers per gene. Recurrent breakage, often accompanied by partial deletion of the genes, was found for NCKAP5, SH3BGR and TTC3 in 3 (0.8%) tumors each, as well as for ARNTL2 and ENOX1 in 2 (0.5%) cancers each. One rearranged tumor sample was observed for each of VCL, ZNF578, IMMP2L, SLC16A12, PANK1, GPHN, LRP1 and ZHX2. Balanced rearrangements, indicating possible gene fusion, were found for ZNF578, SH3BGR, LPR12 and ZHX2 in individual cancers only. The results of the present study confirm that rearrangements involving non-ETS genes occur in prostate cancer, but demonstrate that they are highly individual and typically non-recurrent.

Original languageEnglish
JournalInternational Journal of Oncology
Volume46
Issue number4
Pages (from-to)1637-42
Number of pages6
ISSN1019-6439
DOIs
Publication statusPublished - Apr 2015
Externally publishedYes

ID: 144838759