Joachim Lütken Weischenfeldt

Joachim Lütken Weischenfeldt

Group leader, Clinical Professor

Member of:

    ORCID: 0000-0002-3917-5524

    Publication year:
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    1 - 25 out of 68Page size: 25
    1. 2004

    2. Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis.

      Doherty, T. M., Olsen, A. W., Weischenfeldt, Joachim Lütken, Huygen, K., D'Souza, S., Kondratieva, T. K., Yeremeev, V. V., Apt, A. S., Raupach, B., Grode, L., Kaufmann, S. & Andersen, P., 2004, In: Journal of Infectious Diseases. 190, 12, p. 2146-53 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2005
    4. Published

      Messenger RNA surveillance: neutralizing natural nonsense.

      Weischenfeldt, Joachim Lütken, Lykke-Andersen, J. & Porse, Bo Torben, 2005, In: Current Biology. 15, 14, p. R559-62

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. 2006

    6. Probing the role of Nonsense-mediated mRNA decay in the mammalian organism and cell.

      Weischenfeldt, Joachim Lütken, 2006

      Research output: Book/Report › Ph.D. thesis › Research

    7. 2008
    8. Published

      Bone Marrow-derived Macrophages (BMMs): Isolation and applications.

      Weischenfeldt, Joachim Lütken & Porse, Bo Torben, 2008, In: Cold Spring Harbor Protocols.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

      Weischenfeldt, Joachim Lütken, Damgaard, I., Bryder, D., Theilgaard-Mønch, Kim, Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, Bo Torben, 2008, In: Genes & Development. 22, 10, p. 1381-96 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2010
    11. Published

      UPF2 is a critical regulator of liver development, function and regeneration

      Thoren, L. A., Nørgaard, G. A., Weischenfeldt, Joachim Lütken, Waage, J., Jakobsen, J. S., Damgaard, I., Bergström, F. C., Blom, A. M., Borup, R., Bisgaard, Hanne Cathrine & Porse, Bo Torben, 2010, In: PLoS ONE. 5, 7, p. e11650

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 2012
    13. Published

      Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

      Weischenfeldt, Joachim Lütken, Waage, J. E., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, Karsten, Krogh, Anders, Wang, J. & Porse, Bo Torben, 2012, In: Genome Biology (Online Edition). 13, 5, 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

      Rausch, T., Jones, D. T. W., Zapatka, M., Stütz, A. M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P. A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C. & 31 others, von Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A. E., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D. M., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rücker, F. G., Döhner, K., Döhner, H., Koster, J., Molenaar, J. J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M. D., Lichter, P., Pfister, S. M. & Korbel, J. O., 20 Jan 2012, In: Cell. 148, 1-2, p. 59-71 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Dissecting the genomic complexity underlying medulloblastoma

      Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A. & 70 others, Remke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, Joachim Lütken, Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U. D., Wang, Q., Lasitschka, B., Bartholomae, C. C., Schmidt, M., von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M. J., Russell, R. B., Coco, S., Tonini, G. P., Schüller, U., Hans, V., Graf, N., Kim, Y., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A. E., von Deimling, A., Witt, O., Maass, E., Rössler, J., Ebinger, M., Schuhmann, M. U., Frühwald, M. C., Hasselblatt, M., Jabado, N., Rutkowski, S., von Bueren, A. O., Williamson, D., Clifford, S. C., McCabe, M. G., Collins, V. P., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P. A., Taylor, M. D., Meyerson, M., Pomeroy, S. L., Yaspo, M., Korbel, J. O., Korshunov, A., Eils, R., Pfister, S. M. & Lichter, P., 2 Aug 2012, In: Nature. 488, 7409, p. 100-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. 2013

    17. Phenotypic impact of genomic structural variation: insights from and for human disease

      Weischenfeldt, Joachim Lütken, Symmons, O., Spitz, F. & Korbel, J. O., Feb 2013, In: Nature Reviews. Genetics. 14, 2, p. 125-38 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

      Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H-J., Stehr, H., Rausch, T., Jäger, N., Gu, L., Bogatyrova, O., Stütz, A. M., Claus, R., Eils, J., Eils, R., Gerhäuser, C., Huang, P-H., Hutter, B. & 40 others, Kabbe, R., Lawerenz, C., Radomski, S., Bartholomae, C. C., Fälth, M., Gade, S., Schmidt, M., Amschler, N., Haß, T., Galal, R., Gjoni, J., Kuner, R., Baer, C., Masser, S., von Kalle, C., Zichner, T., Benes, V., Raeder, B., Mader, M., Amstislavskiy, V., Avci, M., Lehrach, H., Parkhomchuk, D., Sultan, M., Burkhardt, L., Graefen, M., Huland, H., Kluth, M., Krohn, A., Sirma, H., Stumm, L., Steurer, S., Grupp, K., Sültmann, H., Sauter, G., Plass, C., Brors, B., Yaspo, M., Korbel, J. O. & Schlomm, T., 11 Feb 2013, In: Cancer Cell. 23, 2, p. 159-70 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. 2014

    20. Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer

      Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C., Plass, C. & 1 others, ICGC Early Onset Prostate Cancer Project, I. E. O. P. C. P., 7 Aug 2014, In: Cell Reports. 8, 3, p. 798-806 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer

      Steurer, S., Mayer, P. S., Adam, M., Krohn, A., Koop, C., Ospina-Klinck, D., Tehrani, A. A., Simon, R., Tennstedt, P., Graefen, M., Wittmer, C., Brors, B., Plass, C., Korbel, J., Weischenfeldt, Joachim Lütken, Sauter, G., Huland, H., Tsourlakis, M. C., Minner, S. & Schlomm, T., Dec 2014, In: European Urology (Italian Edition). 66, 6, p. 978-81 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2015

    23. A cell-based model system links chromothripsis with hyperploidy

      Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, Joachim Lütken, Isokane, M., Stütz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura-Wang, M., Northcott, P., Pfister, S. M., Lichter, P., Ellenberg, J. & Korbel, J. O., 2015, In: Molecular Systems Biology. 11, 9, p. 828

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer

      Kluth, M., Galal, R., Krohn, A., Weischenfeldt, Joachim Lütken, Tsourlakis, C., Paustian, L., Ahrary, R., Ahmed, M., Scherzai, S., Meyer, A., Sirma, H., Korbel, J., Sauter, G., Schlomm, T., Simon, R. & Minner, S., Apr 2015, In: International Journal of Oncology. 46, 4, p. 1637-42 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

      Kunz, J. B., Rausch, T., Bandapalli, O. R., Eilers, J., Pechanska, P., Schuessele, S., Assenov, Y., Stütz, A. M., Kirschner-Schwabe, R., Hof, J., Eckert, C., von Stackelberg, A., Schrappe, M., Stanulla, M., Koehler, R., Avigad, S., Elitzur, S., Handgretinger, R., Benes, V., Weischenfeldt, J. & 3 others, Korbel, J. O., Muckenthaler, M. U. & Kulozik, A. E., 20 Aug 2015, In: Haematologica. p. 1442-1450 8 p., 100.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. The Aging Prostate Is Never "Normal": Implications from the Genomic Characterization of Multifocal Prostate Cancers

      Schlomm, T., Weischenfeldt, Joachim Lütken, Korbel, J. & Sauter, G., Sep 2015, In: European Urology (Italian Edition). 68, 3, p. 348-50 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2016

    28. Immortalization capacity of HPV types is inversely related to chromosomal instability

      Schütze, D. M., Krijgsman, O., Snijders, P. J. F., Ylstra, B., Weischenfeldt, Joachim Lütken, Mardin, B. R., Stütz, A. M., Korbel, J. O., de Winter, J. P., Meijer, C. J. L. M., Quint, W. G. V., Bosch, L., Wilting, S. M. & Steenbergen, R. D. M., 14 Mar 2016, In: OncoTarget. 7, 25, p. 37608-37621 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients

      Tsourlakis, M., Stender, A., Quaas, A., Kluth, M., Wittmer, C., Haese, A., Graefen, M., Steurer, S., Simon, R., Korbel, J., Weischenfeldt, Joachim Lütken, Huland, H., Sauter, G., Schlomm, T. & Minner, S., 17 Aug 2016, In: B M C Cancer. 16, p. 641

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2017
    31. Published

      Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

      Weischenfeldt, J. L., Dubash, T., Drainas, A. P., Mardin, B. R., Chen, Y., Stütz, A. M., Waszak, S. M., Bosco, G., Halvorsen, A. R., Raeder, B., Efthymiopoulos, T., Erkek, S., Siegl, C., Brenner, H., Brustugun, O. T., Dieter, S. M., Northcott, P. A., Petersen, I., Pfister, S. M., Schneider, M. & 12 others, Solberg, S. K., Thunissen, E., Weichert, W., Zichner, T., Thomas, R., Peifer, M., Helland, A., Ball, C. R., Jechlinger, M., Sotillo, R., Glimm, H. & Korbel, J. O., 2017, In: Nature Genetics. 49, 1, p. 65-74 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The whole-genome landscape of medulloblastoma subtypes

      Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M. & 67 others, Zapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y. J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., 19 Jul 2017, In: Nature. 547, 7663, p. 311-317 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Genomes of early onset prostate cancer

      Weischenfeldt, Joachim Lütken & Korbel, J. O., 1 Sep 2017, In: Current Opinion in Urology. 27, 5, p. 481-487 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      Mitochondrial mutations drive prostate cancer aggression

      Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., Van Der Kwast, T., Korbel, J., Schlomm, T., Bristow, R. G. & 1 others, Boutros, P. C., 1 Dec 2017, In: Nature Communications. 8, 1, 8 p., 656.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer

      Kluth, M., Jung, S., Habib, O., Eshagzaiy, M., Heinl, A., Amschler, N., Masser, S., Mader, M., Runte, F., Barow, P., Frogh, S., Omari, J., Möller-Koop, C., Hube-Magg, C., Weischenfeldt, J., Korbel, J., Steurer, S., Krech, T., Huland, H., Graefen, M. & 4 others, Minner, S., Sauter, G., Schlomm, T. & Simon, R., 12 Dec 2017, In: OncoTarget. 8, 65, p. 108923-108935 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2018
    37. Published

      Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

      Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D. & 35 others, Koop, C., Lutsik, P., Matzk, S., Warnatz, H. J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E. M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M. L., Korbel, J. O., Schlomm, T. & Weischenfeldt, Joachim Lütken, 2018, In: Cancer Cell. 34, 6, p. 996-1011.e8 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 3997200