Mitochondrial mutations drive prostate cancer aggression

Research output: Contribution to journal › Journal article › Research › peer-review

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Mitochondrial mutations drive prostate cancer aggression. / Hopkins, Julia F.; Sabelnykova, Veronica Y.; Weischenfeldt, Joachim; Simon, Ronald; Aguiar, Jennifer A.; Alkallas, Rached; Heisler, Lawrence E.; Zhang, Junyan; Watson, John D.; Chua, Melvin L.K.; Fraser, Michael; Favero, Francesco; Lawerenz, Chris; Plass, Christoph; Sauter, Guido; McPherson, John D.; Van Der Kwast, Theodorus; Korbel, Jan; Schlomm, Thorsten; Bristow, Robert G.; Boutros, Paul C.

In: Nature Communications, Vol. 8, No. 1, 656, 01.12.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hopkins, JF, Sabelnykova, VY, Weischenfeldt, J, Simon, R, Aguiar, JA, Alkallas, R, Heisler, LE, Zhang, J, Watson, JD, Chua, MLK, Fraser, M, Favero, F, Lawerenz, C, Plass, C, Sauter, G, McPherson, JD, Van Der Kwast, T, Korbel, J, Schlomm, T, Bristow, RG & Boutros, PC 2017, 'Mitochondrial mutations drive prostate cancer aggression', Nature Communications, vol. 8, no. 1, 656. https://doi.org/10.1038/s41467-017-00377-y

APA

Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., Van Der Kwast, T., Korbel, J., Schlomm, T., ... Boutros, P. C. (2017). Mitochondrial mutations drive prostate cancer aggression. Nature Communications, 8(1), [656]. https://doi.org/10.1038/s41467-017-00377-y

Vancouver

Hopkins JF, Sabelnykova VY, Weischenfeldt J, Simon R, Aguiar JA, Alkallas R et al. Mitochondrial mutations drive prostate cancer aggression. Nature Communications. 2017 Dec 1;8(1). 656. https://doi.org/10.1038/s41467-017-00377-y

Author

Hopkins, Julia F. ; Sabelnykova, Veronica Y. ; Weischenfeldt, Joachim ; Simon, Ronald ; Aguiar, Jennifer A. ; Alkallas, Rached ; Heisler, Lawrence E. ; Zhang, Junyan ; Watson, John D. ; Chua, Melvin L.K. ; Fraser, Michael ; Favero, Francesco ; Lawerenz, Chris ; Plass, Christoph ; Sauter, Guido ; McPherson, John D. ; Van Der Kwast, Theodorus ; Korbel, Jan ; Schlomm, Thorsten ; Bristow, Robert G. ; Boutros, Paul C. / Mitochondrial mutations drive prostate cancer aggression. In: Nature Communications. 2017 ; Vol. 8, No. 1.

Bibtex

@article{a54b9e23fad5485da6cbb1db0d3d4422,
title = "Mitochondrial mutations drive prostate cancer aggression",
abstract = "Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.",
author = "Hopkins, {Julia F.} and Sabelnykova, {Veronica Y.} and Joachim Weischenfeldt and Ronald Simon and Aguiar, {Jennifer A.} and Rached Alkallas and Heisler, {Lawrence E.} and Junyan Zhang and Watson, {John D.} and Chua, {Melvin L.K.} and Michael Fraser and Francesco Favero and Chris Lawerenz and Christoph Plass and Guido Sauter and McPherson, {John D.} and {Van Der Kwast}, Theodorus and Jan Korbel and Thorsten Schlomm and Bristow, {Robert G.} and Boutros, {Paul C.}",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41467-017-00377-y",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Mitochondrial mutations drive prostate cancer aggression

AU - Hopkins, Julia F.

AU - Sabelnykova, Veronica Y.

AU - Weischenfeldt, Joachim

AU - Simon, Ronald

AU - Aguiar, Jennifer A.

AU - Alkallas, Rached

AU - Heisler, Lawrence E.

AU - Zhang, Junyan

AU - Watson, John D.

AU - Chua, Melvin L.K.

AU - Fraser, Michael

AU - Favero, Francesco

AU - Lawerenz, Chris

AU - Plass, Christoph

AU - Sauter, Guido

AU - McPherson, John D.

AU - Van Der Kwast, Theodorus

AU - Korbel, Jan

AU - Schlomm, Thorsten

AU - Bristow, Robert G.

AU - Boutros, Paul C.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.

AB - Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer.

U2 - 10.1038/s41467-017-00377-y

DO - 10.1038/s41467-017-00377-y

M3 - Journal article

C2 - 28939825

AN - SCOPUS:85029742904

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 656

ER -

ID: 185036843