The Neurogenome study: Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients
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The Neurogenome study : Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients. / Nørøxe, Dorte Schou; Maarup, Simone; Fougner, Vincent; Muhic, Aida; Møller, Søren; Urup, Thomas; Lü, Maya Jeje Schuang; Weischenfeldt, Joachim; Hansen, Adam Espe; Skovgaard Poulsen, Hans; Lassen, Ulrik; Hasselbalch, Benedikte.
In: Neuro-Oncology Advances, Vol. 5, No. 1, vdad137, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Neurogenome study
T2 - Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients
AU - Nørøxe, Dorte Schou
AU - Maarup, Simone
AU - Fougner, Vincent
AU - Muhic, Aida
AU - Møller, Søren
AU - Urup, Thomas
AU - Lü, Maya Jeje Schuang
AU - Weischenfeldt, Joachim
AU - Hansen, Adam Espe
AU - Skovgaard Poulsen, Hans
AU - Lassen, Ulrik
AU - Hasselbalch, Benedikte
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
PY - 2023
Y1 - 2023
N2 - Background: Glioblastoma is an aggressive brain cancer with no possibility for cure. Treatment and survival have only improved slightly since 2005 when the current regime was implemented. The limited improvements in the treatment of glioblastoma may reflect our poor understanding of the disease. We hypothesize that systematically collected translational data will improve knowledge and hereby treatment. Methods: We have been performing whole exome sequencing in glioblastoma tumor tissue since 2016 and whole genome sequencing (WGS) since 2020 with the aim of offering experimental treatment. Results: We have sequenced 400+ GBM patients and from these 100+ are paired tumor samples from relapse surgery. To develop genomic profiling and to increase the information on each patient's contribution, we have initiated the Neurogenome study as of June 2022. The Neurogenome protocol is a national, comprehensive, translational, and omic protocol. It is a continuation of 2 previous protocols from 2016 and forth in our department, but with more substudies added, focusing on the translational and clinical utility. We collect and analyze data from an out-patient clinic in a systematic approach to a number of subprojects ranging from basic science to applied clinical science, including clinical trials. Conclusions: The protocol will act as a backbone for future projects in the national research center, Danish Comprehensive Cancer Center-Brain Tumor Center with the overall aim to select eligible patients for experimental treatment based upon genomic alterations. The article will present the Neurogenome setup and a presentation of selected projects that are based upon inclusion.
AB - Background: Glioblastoma is an aggressive brain cancer with no possibility for cure. Treatment and survival have only improved slightly since 2005 when the current regime was implemented. The limited improvements in the treatment of glioblastoma may reflect our poor understanding of the disease. We hypothesize that systematically collected translational data will improve knowledge and hereby treatment. Methods: We have been performing whole exome sequencing in glioblastoma tumor tissue since 2016 and whole genome sequencing (WGS) since 2020 with the aim of offering experimental treatment. Results: We have sequenced 400+ GBM patients and from these 100+ are paired tumor samples from relapse surgery. To develop genomic profiling and to increase the information on each patient's contribution, we have initiated the Neurogenome study as of June 2022. The Neurogenome protocol is a national, comprehensive, translational, and omic protocol. It is a continuation of 2 previous protocols from 2016 and forth in our department, but with more substudies added, focusing on the translational and clinical utility. We collect and analyze data from an out-patient clinic in a systematic approach to a number of subprojects ranging from basic science to applied clinical science, including clinical trials. Conclusions: The protocol will act as a backbone for future projects in the national research center, Danish Comprehensive Cancer Center-Brain Tumor Center with the overall aim to select eligible patients for experimental treatment based upon genomic alterations. The article will present the Neurogenome setup and a presentation of selected projects that are based upon inclusion.
KW - Advanced imaging
KW - Clinical trial
KW - Glioblastoma
KW - Liquid biopsies
KW - Translational study
U2 - 10.1093/noajnl/vdad137
DO - 10.1093/noajnl/vdad137
M3 - Journal article
C2 - 38089638
AN - SCOPUS:85180084630
VL - 5
JO - Neuro-Oncology Advances
JF - Neuro-Oncology Advances
SN - 2632-2498
IS - 1
M1 - vdad137
ER -
ID: 378970701