Krister Wennerberg
Professor
Wennerberg Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- 2024
- Published
Robust scoring of selective drug responses for patient-tailored therapy selection
Chen, Y., He, L., Ianevski, A., Ayuda-Durán, P., Potdar, S., Saarela, J., Miettinen, J. J., Kytölä, S., Miettinen, S., Manninen, M., Heckman, C. A., Enserink, J. M., Wennerberg, Krister & Aittokallio, T., 2024, In: Nature Protocols. 19, p. 60-82Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Standardized assays to monitor drug sensitivity in hematologic cancers
Ayuda-Durán, P., Hermansen, J. U., Giliberto, M., Yin, Y., Hanes, R., Gordon, Sandra, Kuusanmäki, Heikki Aleksi, Brodersen, A. M., Andersen, A. N., Taskén, K., Wennerberg, Krister, Enserink, J. M. & Skånland, S. S., 2023, In: Cell Death Discovery. 9, 13 p., 435.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma
Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells
Denisova, O. V., Merisaari, J., Huhtaniemi, R., Qiao, X., Yetukuri, L., Jumppanen, M., Kaur, A., Pääkkönen, M., von Schantz-Fant, С., Ohlmeyer, M., Wennerberg, Krister, Kauko, O., Koch, R., Aittokallio, T., Taipale, M. & Westermarck, J., 2023, In: Molecular Oncology. 17, 9, p. 1803-1820 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
Kuusanmäki, H., Kytölä, S., Vänttinen, I., Ruokoranta, T., Ranta, A., Huuhtanen, J., Suvela, M., Parsons, A., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Västrik, I., Dufva, O., Siitonen, S., Porkka, K., Wennerberg, K., Heckman, C. A. & 5 others, , 2023, In: Haematologica. 108, 7, p. 1768-1781 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I. M., Nygren, P. J., Klievink, J., Bouhlal, J. O. V., Pölönen, P., Zhang, Q., Adnan Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J. J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M. & 9 others, , 2023, In: Blood. 141, 13, p. 1610-1625Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, , 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer
Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, Krister, 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models
Chalabi Hajkarim, M., Karjalainen, E., Osipovitch, M., Dimopoulos, K., Gordon, Sandra, Ambri, F., Rasmussen, K. D., Grønbæk, Kirsten, Helin, K., Wennerberg, Krister & Won, K., 2022, In: eLife. 11, e73760.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells
Denisova, O. V., Merisaari, J., Kaur, A., Yetukuri, L., Jumppanen, M., von Schantz-Fant, C., Ohlmeyer, M., Wennerberg, Krister, Aittokallio, T., Taipale, M. & Westermarck, J., 2022, In: Scientific Reports. 12, 9 p., 13796.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia
Malani, D., Kumar, A., Brück, O., Kontro, M., Yadav, B., Hellesøy, M., Kuusanmäki, H., Dufva, O., Kankainen, M., Eldfors, S., Potdar, S., Saarela, J., Turunen, L., Parsons, A., Västrik, I., Kivinen, K., Saarela, J., Räty, R., Lehto, M., Wolf, M. & 7 others, , 2022, In: Cancer Discovery. 12, 2, p. 388-401 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status
Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, Krister, Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, Krister, Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics
Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments
Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M. D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, Krister, Vähä-Koskela, M. & Tang, J., 2022, In: Briefings in Bioinformatics. 23, 1, 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Crowdsourced mapping of unexplored target space of kinase inhibitors
Cichonska, A., Ravikumar, B., Allaway, R. J., Wan, F., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C. I., Willson, T. M., Oprea, T. I. & 6 others, , 2021, In: Nature Communications. 12, 1, 18 p., 3307.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer
He, L., Bulanova, Daria, Oikkonen, J., Häkkinen, A., Zhang, K., Zheng, S., Wang, W., Erkan, E. P., Carpén, O., Joutsiniemi, T., Hietanen, S., Hynninen, J., Huhtinen, K., Hautaniemi, S., Vähärautio, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2021, In: Briefings in Bioinformatics. 22, 6, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
Ianevski, A., Lahtela, J., Javarappa, K. K., Sergeev, P., Ghimire, B. R., Gautam, P., Vähä-Koskela, M., Turunen, L., Linnavirta, N., Kuusanmäki, Heikki Aleksi, Kontro, M., Porkka, K., Heckman, C. A., Mattila, P., Wennerberg, Krister, Giri, A. K. & Aittokallio, T., 2021, In: Science Advances. 7, 8, eabe4038.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Jaiswal, A., Gautam, P., Pietilä, E. A., Timonen, S., Nordström, N., Akimov, Y., Sipari, N., Tanoli, Z., Fleischer, T., Lehti, K., Wennerberg, Krister & Aittokallio, T., 2021, In: Molecular Systems Biology. 17, 3, p. 1-25 e9526.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective drug combination vulnerabilities in STAT3- And TP53-mutant malignant NK cells
Parri, E., Kuusanmäki, Heikki Aleksi, Bulanova, Daria, Mustjoki, S. & Wennerberg, Krister, 2021, In: Blood advances. 5, 7, p. 1862-1875Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploration of databases and methods supporting drug repurposing: A comprehensive survey
Tanoli, Z., Seemab, U., Scherer, A., Wennerberg, Krister, Tang, J. & Vähä-Koskela, M., 2021, In: Briefings in Bioinformatics. 22, 2, p. 1656-1678 23 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia
White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, Heikki Aleksi, Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, Krister & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics
Akimov, Y., Bulanova, Daria, Timonen, S., Wennerberg, Krister & Aittokallio, T., 2020, In: Molecular Systems Biology. 16, 3, p. 1-18 e9195.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abstract P6-10-28: Therapeutic stratification of triple negative breast cancer by integrating chemosensitivity & phospho-proteome profiles
Gautam, P., Qin, X., Vainonen, J., Nagelli, S., Lampe, J., Klefström, J., Westermarck, J., Wennerberg, Krister & Aittokallio, T., 2020.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening
Gupta, A., Gautam, P., Wennerberg, Krister & Aittokallio, T., 2020, In: Communications Biology. 3, 1, p. 1-12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma
Hansson, K., Radke, K., Aaltonen, K., Saarela, J., Mañas, A., Sjölund, J., Smith, E. M., Pietras, K., Påhlman, S., Wennerberg, Krister, Gisselsson, D. & Bexell, D., 2020, In: Science Translational Medicine. 12, 562, p. 1-17 eaba4434.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer
Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L. & 8 others, , 2020, In: Cancer Discovery. 10, 1, p. 104-123 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors
Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, Krister, Hautaniemi, S. & Carpén, O., 2020, In: Journal of Pathology. 250, 2, p. 159-169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1
Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., Pavic, K., Aakula, A., Rupp, C., Jumppanen, M., Haapaniemi, P., Ruan, L., Yadav, B., Suni, V., Varila, T., Corthals, G. L., Reimand, J., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., 2020, In: Journal of Biological Chemistry. 295, 13, p. 4194-4211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia
Kriegbaum, M. C. & Wennerberg, Krister, 2020, In: Cancer Cell. 38, 6, p. 776-778 3 p.Research output: Contribution to journal › Journal article › Research
- Published
Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types
Majumder, M. M., Leppä, A., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O’gorman, P., Wennerberg, Krister, Porkka, K., Gjertsen, B. T. & Heckman, C. A., 2020, In: Haematologica. 105, 6, p. 1527-1538Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia
Malani, D., Yadav, B., Kumar, A., Potdar, S., Kontro, M., Kankainen, M., Javarappa, K. K., Porkka, K., Wolf, M., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Murumägi, A. & Kallioniemi, O., 2020, In: Leukemia. 34, p. 2780-2784Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel regulators of STAT3 activity
Parri, E., Kuusanmäki, Heikki Aleksi, Van Adrichem, A. J., Kaustio, M. & Wennerberg, Krister, 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breeze: an integrated quality control and data analysis application for high-throughput drug screening
Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition
Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing
Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, Krister, Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing
Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, Krister, Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas
Brodin, B. A., Wennerberg, Krister, Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., Von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 2019, In: British Journal of Cancer. 120, 4, p. 435-443 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abstract P2-06-25: A phenotypic screening and machine learning platform efficiently identifies triple negative breast cancer-selective and readily druggable targets
Gautam, P., Jaiswal, A., Aittokallio, T., Hassan, A. & Wennerberg, Krister, 2019, In: Cancer Research. p. P2-06-25-P2-06-25Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Drug screening and molecular profiling identifies INKA1 as a predictive biomarker for sensitivity to MAPK inhibition-antimitotic combination treatment in pancreatic ductal adenocarcinoma
Gautam, P., Vaha-Koskela, M., Tomlinson, M., Cox, A. D., Der, C. J., Aittokallio, T. & Wennerberg, Krister, 2019, In: Molecular Cancer Therapeutics. 18, 12, A137.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets
Gautam, P., Jaiswal, A., Aittokallio, T., Al-ali, H. & Wennerberg, Krister, 2019, In: Cell Chemical Biology. 26, 7, p. 970-979Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of drug combination effects with a minimal set of experiments
Ianevski, A., Giri, A. K., Gautam, P., Kononov, A., Potdar, S., Saarela, J., Wennerberg, Krister & Aittokallio, T., 2019, In: Nature Machine Intelligence. 1, 12, p. 568-577Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies
Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers
Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer
Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach
Ali, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Apr 2018, In: Bioinformatics (Online). 34, 8, p. 1353-1362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Dyczynski, M., Yu, Y., Otrocka, M., Parpal, S., Braga, T., Henley, A. B., Zazzi, H., Lerner, M., Wennerberg, Krister, Viklund, J., Martinsson, J., Grandér, D., De Milito, A. & Pokrovskaja Tamm, K., 2018, In: Cancer Letters. 435, p. 32-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Methods for High-throughput Drug Combination Screening and Synergy Scoring
He, L., Kulesskiy, E., Saarela, J., Turunen, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2018, In: Methods in molecular biology (Clifton, N.J.). 1711, p. 351-398 48 p.Research output: Contribution to journal › Journal article › Research › peer-review
Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients
He, L., Tang, J., Andersson, E. I., Timonen, S., Koschmieder, S., Wennerberg, Krister, Mustjoki, S. & Aittokallio, T., 1 May 2018, In: Cancer Research. 78, 9, p. 2407-2418 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Toward universal protein post-translational modification detection in high throughput format
Härmä, H., Tong-Ochoa, N., van Adrichem, A. J., Jelesarov, I., Wennerberg, Krister & Kopra, K., 2018, In: Chemical communications (Cambridge, England). 54, 23, p. 2910-2913 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
Kauko, O., O’Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, Krister, Narla, G. & Westermarck, J., 18 Jul 2018, In: Science Translational Medicine. 10, 450, p. 1-12 12 p., eaaq1093.Research output: Contribution to journal › Journal article › Research › peer-review
Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy
Lepikhova, T., Karhemo, P. R., Louhimo, R., Yadav, B., Murumagi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjanen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, Krister, Joensuu, H. & Monni, O., 2018, In: Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, , 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.Research output: Contribution to journal › Journal article › Research › peer-review
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, , 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression
Ammad-Ud-Din, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Jul 2017, In: Bioinformatics (Online). 33, 14, p. i359-i368Research output: Contribution to journal › Journal article › Research › peer-review
Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
Cichonska, A., Ravikumar, B., Parri, E., Timonen, S., Pahikkala, T., Airola, A., Wennerberg, Krister, Rousu, J. & Aittokallio, T., Aug 2017, In: PLOS Computational Biology. 13, 8, p. e1005678Research output: Contribution to journal › Journal article › Research › peer-review
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines
Broad-DREAM Community, B. C., 22 Nov 2017, In: Cell Systems. 5, 5, p. 485-497.e3Research output: Contribution to journal › Journal article › Research › peer-review
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells
Haltia, U., Andersson, N., Yadav, B., Färkkilä, A., Kulesskiy, E., Kankainen, M., Tang, J., Bützow, R., Riska, A., Leminen, A., Heikinheimo, M., Kallioniemi, O., Unkila-Kallio, L., Wennerberg, Krister, Aittokallio, T. & Anttonen, M., Mar 2017, In: Gynecologic Oncology. 144, 3, p. 621-630 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells
Jaiswal, A., Peddinti, G., Akimov, Y., Wennerberg, Krister, Kuznetsov, S., Tang, J. & Aittokallio, T., 1 Jun 2017, In: Genome Medicine. 9, 1, p. 51Research output: Contribution to journal › Journal article › Research › peer-review
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML
Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Mayoral Safont, M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, , 10 Aug 2017, In: Blood. 130, 6, p. 789-802 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury
Kohonen, P., Parkkinen, J. A., Willighagen, E. L., Ceder, R., Wennerberg, Krister, Kaski, S. & Grafström, R. C., 3 Jul 2017, In: Nature Communications. 8, p. 15932Research output: Contribution to journal › Journal article › Research › peer-review
High-Throughput Dual Screening Method for Ras Activities and Inhibitors
Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, Krister & Härmä, H., 18 Apr 2017, In: Analytical Chemistry. 89, 8, p. 4508-4516 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, Krister, Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In: OncoTarget. 8, 57, p. 97516-97527 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer
Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells
Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, Krister, 10 May 2016, In: Molecular Cancer. 15, 1, p. 34Research output: Contribution to journal › Journal article › Research › peer-review
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, , 11 Jan 2016, In: Cancer Cell. 29, 1, p. 75-89 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing
Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, Krister, Feb 2016, In: Journal of laboratory automation. 21, 1, p. 27-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease
Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, Krister & Saarma, M., 2016, In: Frontiers in Aging Neuroscience. 8, p. 254Research output: Contribution to journal › Review › Research › peer-review
Consistency in drug response profiling
Mpindi, J. P., Yadav, B., Östling, P., Gautam, P., Malani, D., Murumägi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, Krister, Kallioniemi, O. & Aittokallio, T., 30 Nov 2016, In: Nature. 540, 7631, p. E5-E6Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses
Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cancer Cell Drug Response Transcriptomes in 3D
Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth
Al-Ali, H., Lee, D., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, Krister, Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., 21 Aug 2015, In: ACS chemical biology. 10, 8, p. 1939-51 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening
Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, Krister & Vidugiriene, J., Oct 2015, In: ASSAY and Drug Development Technologies. 13, 8, p. 456-65 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples
He, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 1 Jun 2015, In: Bioinformatics (Online). 31, 11, p. 1866-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products
Kibble, M., Saarinen, N., Tang, J., Wennerberg, Krister, Mäkelä, S. & Aittokallio, T., Aug 2015, In: Natural Product Reports. 32, 8, p. 1249-66 18 p.Research output: Contribution to journal › Review › Research › peer-review
KIFC1 is a novel potential therapeutic target for breast cancer
Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, Krister, Xu, B. & Zhang, W., 2015, In: Cancer Biology & Therapy. 16, 9, p. 1316-22 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data
Mpindi, J., Swapnil, P., Dmitrii, B., Jani, S., Saeed, K., Wennerberg, Krister, Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In: Bioinformatics (Online). 31, 23, p. 3815-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data
Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles
Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
What is synergy? The Saariselkä agreement revisited
Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181Research output: Contribution to journal › Review › Research › peer-review
From drug response profiling to target addiction scoring in cancer cell models
Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model
Yadav, B., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2015, In: Computational and Structural Biotechnology Journal. 13, p. 504-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP
van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity
van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization
Ammad-ud-din, M., Georgii, E., Gönen, M., Laitinen, T., Kallioniemi, O., Wennerberg, Krister, Poso, A. & Kaski, S., 25 Aug 2014, In: Journal of Chemical Information and Modeling. 54, 8, p. 2347-59 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells
Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, Krister, Yli-Kauhaluoma, J., Huttunen, H. J., Castrén, E. & Rantamäki, T., 30 Jan 2014, In: Journal of Neuroscience Methods. 222, p. 142-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza
Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, Krister & Noah, J. W., Jul 2014, In: Journal of Biomolecular Screening. 19, 6, p. 936-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
A community effort to assess and improve drug sensitivity prediction algorithms
NCI DREAM Community, N. D. C., Dec 2014, In: Nature Biotechnology. 32, 12, p. 1202-12 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis
Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, Krister, Poso, A. & Kaski, S., 1 Sep 2014, In: Bioinformatics (Online). 30, 17, p. i497-504Research output: Contribution to journal › Journal article › Research › peer-review
The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine
Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Antifungal application of nonantifungal drugs
Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis
Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening
Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, , Dec 2013, In: Cancer Discovery. 3, 12, p. 1416-29 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways
Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, Krister & Aittokallio, T., 2013, In: PLOS Computational Biology. 9, 9, p. e1003226Research output: Contribution to journal › Journal article › Research › peer-review
A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis
Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, Krister, Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1644-60 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs
Khan, S. A., Faisal, A., Mpindi, J. P., Parkkinen, J. A., Kalliokoski, T., Poso, A., Kallioniemi, O. P., Wennerberg, Krister & Kaski, S., 30 May 2012, In: BMC Bioinformatics. 13, p. 112Research output: Contribution to journal › Journal article › Research › peer-review
Somatic STAT3 mutations in large granular lymphocytic leukemia
Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A. & 9 others, , 17 May 2012, In: The New England Journal of Medicine. 366, 20, p. 1905-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening
Manuvakhova, M. S., Johnson, G. G., White, M. C., Ananthan, S., Sosa, M., Maddox, C., McKellip, S., Rasmussen, L., Wennerberg, Krister, Hobrath, J. V., White, E. L., Maddry, J. A. & Grimaldi, M., Jan 2011, In: Journal of Neuroscience Research. 89, 1, p. 58-72 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
A high-throughput screen for chemical inhibitors of exocytic transport in yeast
Zhang, L., Nebane, N. M., Wennerberg, Krister, Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 Jun 2010, In: ChemBioChem. 11, 9, p. 1291-301 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF
Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin
Dubash, A. D., Wennerberg, Krister, García-Mata, R., Menold, M. M., Arthur, W. T. & Burridge, K., 15 Nov 2007, In: Journal of Cell Science. 120, Pt 22, p. 3989-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
Analysis of activated GAPs and GEFs in cell lysates
García-Mata, R., Wennerberg, Krister, Arthur, W. T., Noren, N. K., Ellerbroek, S. M. & Burridge, K., 2006, In: Methods in Enzymology. 406, p. 425-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
The Ras superfamily at a glance
Wennerberg, Krister, Rossman, K. L. & Der, C. J., 1 Mar 2005, In: Journal of Cell Science. 118, Pt 5, p. 843-6 4 p.Research output: Contribution to journal › Review › Research › peer-review
- 2004
p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation
Aitsebaomo, J., Wennerberg, Krister, Der, C. J., Zhang, C., Kedar, V., Moser, M., Kingsley-Kallesen, M. L., Zeng, G. & Patterson, C., 23 Apr 2004, In: The Journal of Biological Chemistry. 279, 17, p. 17963-72 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rho and Rac take center stage
Burridge, K. & Wennerberg, Krister, 23 Jan 2004, In: Cell. 116, 2, p. 167-79 13 p.Research output: Contribution to journal › Review › Research › peer-review
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
Ellerbroek, S. M., Wennerberg, Krister, Arthur, W. T., Dunty, J. M., Bowman, D. R., DeMali, K. A., Der, C. & Burridge, K., Jul 2004, In: Molecular Biology of the Cell. 15, 7, p. 3309-19 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rho-family GTPases: it's not only Rac and Rho (and I like it)
Wennerberg, Krister & Der, C. J., 15 Mar 2004, In: Journal of Cell Science. 117, Pt 8, p. 1301-12 12 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
Integrin signaling to the actin cytoskeleton
DeMali, K. A., Wennerberg, Krister & Burridge, K., Oct 2003, In: Current Opinion in Cell Biology. 15, 5, p. 572-82 11 p.Research output: Contribution to journal › Review › Research › peer-review
Serine phosphorylation negatively regulates RhoA in vivo
Ellerbroek, S. M., Wennerberg, Krister & Burridge, K., 23 May 2003, In: The Journal of Biological Chemistry. 278, 21, p. 19023-31 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP
Wennerberg, Krister, Forget, M., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 Jul 2003, In: Current biology : CB. 13, 13, p. 1106-15 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K. & Wennerberg, Krister, 8 Nov 2002, In: The Journal of Biological Chemistry. 277, 45, p. 42964-72 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1
Velling, T., Risteli, J., Wennerberg, Krister, Mosher, D. F. & Johansson, S., 4 Oct 2002, In: The Journal of Biological Chemistry. 277, 40, p. 37377-81 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
RhoG signals in parallel with Rac1 and Cdc42
Wennerberg, Krister, Ellerbroek, S. M., Liu, R., Karnoub, A. E., Burridge, K. & Der, C. J., 6 Dec 2002, In: The Journal of Biological Chemistry. 277, 49, p. 47810-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 181406515
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Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
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