Krister Wennerberg

Krister Wennerberg

Professor

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    ORCID: 0000-0002-1352-4220

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    1. 2002

    2. Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1

      Velling, T., Risteli, J., Wennerberg, Krister, Mosher, D. F. & Johansson, S., 4 Oct 2002, In: The Journal of Biological Chemistry. 277, 40, p. 37377-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

      Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K. & Wennerberg, Krister, 8 Nov 2002, In: The Journal of Biological Chemistry. 277, 45, p. 42964-72 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. RhoG signals in parallel with Rac1 and Cdc42

      Wennerberg, Krister, Ellerbroek, S. M., Liu, R., Karnoub, A. E., Burridge, K. & Der, C. J., 6 Dec 2002, In: The Journal of Biological Chemistry. 277, 49, p. 47810-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. 2003

    6. Serine phosphorylation negatively regulates RhoA in vivo

      Ellerbroek, S. M., Wennerberg, Krister & Burridge, K., 23 May 2003, In: The Journal of Biological Chemistry. 278, 21, p. 19023-31 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

      Wennerberg, Krister, Forget, M., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 Jul 2003, In: Current biology : CB. 13, 13, p. 1106-15 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Integrin signaling to the actin cytoskeleton

      DeMali, K. A., Wennerberg, Krister & Burridge, K., Oct 2003, In: Current Opinion in Cell Biology. 15, 5, p. 572-82 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    9. 2004

    10. Rho and Rac take center stage

      Burridge, K. & Wennerberg, Krister, 23 Jan 2004, In: Cell. 116, 2, p. 167-79 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Rho-family GTPases: it's not only Rac and Rho (and I like it)

      Wennerberg, Krister & Der, C. J., 15 Mar 2004, In: Journal of Cell Science. 117, Pt 8, p. 1301-12 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    12. p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation

      Aitsebaomo, J., Wennerberg, Krister, Der, C. J., Zhang, C., Kedar, V., Moser, M., Kingsley-Kallesen, M. L., Zeng, G. & Patterson, C., 23 Apr 2004, In: The Journal of Biological Chemistry. 279, 17, p. 17963-72 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

      Ellerbroek, S. M., Wennerberg, Krister, Arthur, W. T., Dunty, J. M., Bowman, D. R., DeMali, K. A., Der, C. & Burridge, K., Jul 2004, In: Molecular Biology of the Cell. 15, 7, p. 3309-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2005

    15. The Ras superfamily at a glance

      Wennerberg, Krister, Rossman, K. L. & Der, C. J., 1 Mar 2005, In: Journal of Cell Science. 118, Pt 5, p. 843-6 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    16. 2006

    17. Analysis of activated GAPs and GEFs in cell lysates

      García-Mata, R., Wennerberg, Krister, Arthur, W. T., Noren, N. K., Ellerbroek, S. M. & Burridge, K., 2006, In: Methods in Enzymology. 406, p. 425-37 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2007

    19. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin

      Dubash, A. D., Wennerberg, Krister, García-Mata, R., Menold, M. M., Arthur, W. T. & Burridge, K., 15 Nov 2007, In: Journal of Cell Science. 120, Pt 22, p. 3989-98 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2008

    21. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

      Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2010

    23. A high-throughput screen for chemical inhibitors of exocytic transport in yeast

      Zhang, L., Nebane, N. M., Wennerberg, Krister, Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 Jun 2010, In: ChemBioChem. 11, 9, p. 1291-301 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2011

    25. Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

      Manuvakhova, M. S., Johnson, G. G., White, M. C., Ananthan, S., Sosa, M., Maddox, C., McKellip, S., Rasmussen, L., Wennerberg, Krister, Hobrath, J. V., White, E. L., Maddry, J. A. & Grimaldi, M., Jan 2011, In: Journal of Neuroscience Research. 89, 1, p. 58-72 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2012

    27. Somatic STAT3 mutations in large granular lymphocytic leukemia

      Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A. & 9 others, Knowles, J., Saarela, J., Wennerberg, Krister, Kallioniemi, O., Porkka, K., Loughran, T. P., Heckman, C. A., Maciejewski, J. P. & Mustjoki, S., 17 May 2012, In: The New England Journal of Medicine. 366, 20, p. 1905-13 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

      Khan, S. A., Faisal, A., Mpindi, J. P., Parkkinen, J. A., Kalliokoski, T., Poso, A., Kallioniemi, O. P., Wennerberg, Krister & Kaski, S., 30 May 2012, In: BMC Bioinformatics. 13, p. 112

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2013

    30. Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

      Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, Krister & Aittokallio, T., 2013, In: PLOS Computational Biology. 9, 9, p. e1003226

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

      Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

      Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, Krister, Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1644-60 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

      Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumägi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Rämet, M. E., Suvela, M., Turunen, L., Västrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, Krister, Dec 2013, In: Cancer Discovery. 3, 12, p. 1416-29 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. 2014

    35. Antifungal application of nonantifungal drugs

      Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

      Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, Krister, Yli-Kauhaluoma, J., Huttunen, H. J., Castrén, E. & Rantamäki, T., 30 Jan 2014, In: Journal of Neuroscience Methods. 222, p. 142-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

      Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

      Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza

      Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, Krister & Noah, J. W., Jul 2014, In: Journal of Biomolecular Screening. 19, 6, p. 936-46 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

      Ammad-ud-din, M., Georgii, E., Gönen, M., Laitinen, T., Kallioniemi, O., Wennerberg, Krister, Poso, A. & Kaski, S., 25 Aug 2014, In: Journal of Chemical Information and Modeling. 54, 8, p. 2347-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis

      Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, Krister, Poso, A. & Kaski, S., 1 Sep 2014, In: Bioinformatics (Online). 30, 17, p. i497-504

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. A community effort to assess and improve drug sensitivity prediction algorithms

      NCI DREAM Community, N. D. C., Dec 2014, In: Nature Biotechnology. 32, 12, p. 1202-12 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening

      Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. 2015

    46. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP

      van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. KIFC1 is a novel potential therapeutic target for breast cancer

      Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, Krister, Xu, B. & Zhang, W., 2015, In: Cancer Biology & Therapy. 16, 9, p. 1316-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

      Yadav, B., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2015, In: Computational and Structural Biotechnology Journal. 13, p. 504-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. What is synergy? The Saariselkä agreement revisited

      Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181

      Research output: Contribution to journal › Review › Research › peer-review

    50. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

      Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

      He, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 1 Jun 2015, In: Bioinformatics (Online). 31, 11, p. 1866-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

      Kibble, M., Saarinen, N., Tang, J., Wennerberg, Krister, Mäkelä, S. & Aittokallio, T., Aug 2015, In: Natural Product Reports. 32, 8, p. 1249-66 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    53. Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

      Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

      Al-Ali, H., Lee, D., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, Krister, Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., 21 Aug 2015, In: ACS chemical biology. 10, 8, p. 1939-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

      Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, Krister & Vidugiriene, J., Oct 2015, In: ASSAY and Drug Development Technologies. 13, 8, p. 456-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. From drug response profiling to target addiction scoring in cancer cell models

      Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

      Mpindi, J., Swapnil, P., Dmitrii, B., Jani, S., Saeed, K., Wennerberg, Krister, Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In: Bioinformatics (Online). 31, 23, p. 3815-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

      van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. 2016

    61. c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

      Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, Krister & Saarma, M., 2016, In: Frontiers in Aging Neuroscience. 8, p. 254

      Research output: Contribution to journal › Review › Research › peer-review

    62. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

      Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, Nelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In: Cancer Cell. 29, 1, p. 75-89 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

      Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing

      Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, Krister, Feb 2016, In: Journal of laboratory automation. 21, 1, p. 27-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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