Krister Wennerberg

Krister Wennerberg

Professor

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    ORCID: 0000-0002-1352-4220

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    1. 2002

    2. Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1

      Velling, T., Risteli, J., Wennerberg, Krister, Mosher, D. F. & Johansson, S., 4 Oct 2002, In: The Journal of Biological Chemistry. 277, 40, p. 37377-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

      Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K. & Wennerberg, Krister, 8 Nov 2002, In: The Journal of Biological Chemistry. 277, 45, p. 42964-72 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. RhoG signals in parallel with Rac1 and Cdc42

      Wennerberg, Krister, Ellerbroek, S. M., Liu, R., Karnoub, A. E., Burridge, K. & Der, C. J., 6 Dec 2002, In: The Journal of Biological Chemistry. 277, 49, p. 47810-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. 2003

    6. Serine phosphorylation negatively regulates RhoA in vivo

      Ellerbroek, S. M., Wennerberg, Krister & Burridge, K., 23 May 2003, In: The Journal of Biological Chemistry. 278, 21, p. 19023-31 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

      Wennerberg, Krister, Forget, M., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 Jul 2003, In: Current biology : CB. 13, 13, p. 1106-15 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Integrin signaling to the actin cytoskeleton

      DeMali, K. A., Wennerberg, Krister & Burridge, K., Oct 2003, In: Current Opinion in Cell Biology. 15, 5, p. 572-82 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    9. 2004

    10. Rho and Rac take center stage

      Burridge, K. & Wennerberg, Krister, 23 Jan 2004, In: Cell. 116, 2, p. 167-79 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Rho-family GTPases: it's not only Rac and Rho (and I like it)

      Wennerberg, Krister & Der, C. J., 15 Mar 2004, In: Journal of Cell Science. 117, Pt 8, p. 1301-12 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    12. p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation

      Aitsebaomo, J., Wennerberg, Krister, Der, C. J., Zhang, C., Kedar, V., Moser, M., Kingsley-Kallesen, M. L., Zeng, G. & Patterson, C., 23 Apr 2004, In: The Journal of Biological Chemistry. 279, 17, p. 17963-72 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

      Ellerbroek, S. M., Wennerberg, Krister, Arthur, W. T., Dunty, J. M., Bowman, D. R., DeMali, K. A., Der, C. & Burridge, K., Jul 2004, In: Molecular Biology of the Cell. 15, 7, p. 3309-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2005

    15. The Ras superfamily at a glance

      Wennerberg, Krister, Rossman, K. L. & Der, C. J., 1 Mar 2005, In: Journal of Cell Science. 118, Pt 5, p. 843-6 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    16. 2006

    17. Analysis of activated GAPs and GEFs in cell lysates

      García-Mata, R., Wennerberg, Krister, Arthur, W. T., Noren, N. K., Ellerbroek, S. M. & Burridge, K., 2006, In: Methods in Enzymology. 406, p. 425-37 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2007

    19. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin

      Dubash, A. D., Wennerberg, Krister, García-Mata, R., Menold, M. M., Arthur, W. T. & Burridge, K., 15 Nov 2007, In: Journal of Cell Science. 120, Pt 22, p. 3989-98 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2008

    21. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

      Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2010

    23. A high-throughput screen for chemical inhibitors of exocytic transport in yeast

      Zhang, L., Nebane, N. M., Wennerberg, Krister, Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 Jun 2010, In: ChemBioChem. 11, 9, p. 1291-301 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2011

    25. Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

      Manuvakhova, M. S., Johnson, G. G., White, M. C., Ananthan, S., Sosa, M., Maddox, C., McKellip, S., Rasmussen, L., Wennerberg, Krister, Hobrath, J. V., White, E. L., Maddry, J. A. & Grimaldi, M., Jan 2011, In: Journal of Neuroscience Research. 89, 1, p. 58-72 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2012

    27. Somatic STAT3 mutations in large granular lymphocytic leukemia

      Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A. & 9 others, Knowles, J., Saarela, J., Wennerberg, Krister, Kallioniemi, O., Porkka, K., Loughran, T. P., Heckman, C. A., Maciejewski, J. P. & Mustjoki, S., 17 May 2012, In: The New England Journal of Medicine. 366, 20, p. 1905-13 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

      Khan, S. A., Faisal, A., Mpindi, J. P., Parkkinen, J. A., Kalliokoski, T., Poso, A., Kallioniemi, O. P., Wennerberg, Krister & Kaski, S., 30 May 2012, In: BMC Bioinformatics. 13, p. 112

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2013

    30. Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

      Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, Krister & Aittokallio, T., 2013, In: PLOS Computational Biology. 9, 9, p. e1003226

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

      Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

      Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, Krister, Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1644-60 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

      Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumägi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Rämet, M. E., Suvela, M., Turunen, L., Västrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, Krister, Dec 2013, In: Cancer Discovery. 3, 12, p. 1416-29 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. 2014

    35. Antifungal application of nonantifungal drugs

      Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

      Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, Krister, Yli-Kauhaluoma, J., Huttunen, H. J., Castrén, E. & Rantamäki, T., 30 Jan 2014, In: Journal of Neuroscience Methods. 222, p. 142-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

      Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

      Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza

      Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, Krister & Noah, J. W., Jul 2014, In: Journal of Biomolecular Screening. 19, 6, p. 936-46 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

      Ammad-ud-din, M., Georgii, E., Gönen, M., Laitinen, T., Kallioniemi, O., Wennerberg, Krister, Poso, A. & Kaski, S., 25 Aug 2014, In: Journal of Chemical Information and Modeling. 54, 8, p. 2347-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis

      Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, Krister, Poso, A. & Kaski, S., 1 Sep 2014, In: Bioinformatics (Online). 30, 17, p. i497-504

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. A community effort to assess and improve drug sensitivity prediction algorithms

      NCI DREAM Community, N. D. C., Dec 2014, In: Nature Biotechnology. 32, 12, p. 1202-12 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening

      Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. 2015

    46. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP

      van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. KIFC1 is a novel potential therapeutic target for breast cancer

      Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, Krister, Xu, B. & Zhang, W., 2015, In: Cancer Biology & Therapy. 16, 9, p. 1316-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

      Yadav, B., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2015, In: Computational and Structural Biotechnology Journal. 13, p. 504-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. What is synergy? The Saariselkä agreement revisited

      Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181

      Research output: Contribution to journal › Review › Research › peer-review

    50. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

      Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

      He, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 1 Jun 2015, In: Bioinformatics (Online). 31, 11, p. 1866-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

      Kibble, M., Saarinen, N., Tang, J., Wennerberg, Krister, Mäkelä, S. & Aittokallio, T., Aug 2015, In: Natural Product Reports. 32, 8, p. 1249-66 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    53. Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

      Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

      Al-Ali, H., Lee, D., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, Krister, Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., 21 Aug 2015, In: ACS chemical biology. 10, 8, p. 1939-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

      Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, Krister & Vidugiriene, J., Oct 2015, In: ASSAY and Drug Development Technologies. 13, 8, p. 456-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. From drug response profiling to target addiction scoring in cancer cell models

      Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

      Mpindi, J., Swapnil, P., Dmitrii, B., Jani, S., Saeed, K., Wennerberg, Krister, Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In: Bioinformatics (Online). 31, 23, p. 3815-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

      van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. 2016

    61. c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

      Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, Krister & Saarma, M., 2016, In: Frontiers in Aging Neuroscience. 8, p. 254

      Research output: Contribution to journal › Review › Research › peer-review

    62. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

      Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, Nelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In: Cancer Cell. 29, 1, p. 75-89 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

      Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing

      Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, Krister, Feb 2016, In: Journal of laboratory automation. 21, 1, p. 27-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

      Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, Krister, 10 May 2016, In: Molecular Cancer. 15, 1, p. 34

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Cancer Cell Drug Response Transcriptomes in 3D

      Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Consistency in drug response profiling

      Mpindi, J. P., Yadav, B., Östling, P., Gautam, P., Malani, D., Murumägi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, Krister, Kallioniemi, O. & Aittokallio, T., 30 Nov 2016, In: Nature. 540, 7631, p. E5-E6

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. 2017

    69. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

      Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells

      Haltia, U., Andersson, N., Yadav, B., Färkkilä, A., Kulesskiy, E., Kankainen, M., Tang, J., Bützow, R., Riska, A., Leminen, A., Heikinheimo, M., Kallioniemi, O., Unkila-Kallio, L., Wennerberg, Krister, Aittokallio, T. & Anttonen, M., Mar 2017, In: Gynecologic Oncology. 144, 3, p. 621-630 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

      Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. High-Throughput Dual Screening Method for Ras Activities and Inhibitors

      Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, Krister & Härmä, H., 18 Apr 2017, In: Analytical Chemistry. 89, 8, p. 4508-4516 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

      Jaiswal, A., Peddinti, G., Akimov, Y., Wennerberg, Krister, Kuznetsov, S., Tang, J. & Aittokallio, T., 1 Jun 2017, In: Genome Medicine. 9, 1, p. 51

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

      Kohonen, P., Parkkinen, J. A., Willighagen, E. L., Ceder, R., Wennerberg, Krister, Kaski, S. & Grafström, R. C., 3 Jul 2017, In: Nature Communications. 8, p. 15932

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression

      Ammad-Ud-Din, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Jul 2017, In: Bioinformatics (Online). 33, 14, p. i359-i368

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

      Cichonska, A., Ravikumar, B., Parri, E., Timonen, S., Pahikkala, T., Airola, A., Wennerberg, Krister, Rousu, J. & Aittokallio, T., Aug 2017, In: PLOS Computational Biology. 13, 8, p. e1005678

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

      Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Mayoral Safont, M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In: Blood. 130, 6, p. 789-802 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

      Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, Krister, Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In: OncoTarget. 8, 57, p. 97516-97527 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

      Broad-DREAM Community, B. C., 22 Nov 2017, In: Cell Systems. 5, 5, p. 485-497.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. 2018
    81. Published

      Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

      Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy

      Lepikhova, T., Karhemo, P. R., Louhimo, R., Yadav, B., Murumagi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjanen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, Krister, Joensuu, H. & Monni, O., 2018, In: Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

      Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Methods for High-throughput Drug Combination Screening and Synergy Scoring

      He, L., Kulesskiy, E., Saarela, J., Turunen, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2018, In: Methods in molecular biology (Clifton, N.J.). 1711, p. 351-398 48 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

      Dyczynski, M., Yu, Y., Otrocka, M., Parpal, S., Braga, T., Henley, A. B., Zazzi, H., Lerner, M., Wennerberg, Krister, Viklund, J., Martinsson, J., Grandér, D., De Milito, A. & Pokrovskaja Tamm, K., 2018, In: Cancer Letters. 435, p. 32-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Toward universal protein post-translational modification detection in high throughput format

      Härmä, H., Tong-Ochoa, N., van Adrichem, A. J., Jelesarov, I., Wennerberg, Krister & Kopra, K., 2018, In: Chemical communications (Cambridge, England). 54, 23, p. 2910-2913 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

      Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, Hersey, A., Leach, A. R., Overington, J. P., Repasky, G., Wennerberg, Krister & Aittokallio, T., 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach

      Ali, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Apr 2018, In: Bioinformatics (Online). 34, 8, p. 1353-1362 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients

      He, L., Tang, J., Andersson, E. I., Timonen, S., Koschmieder, S., Wennerberg, Krister, Mustjoki, S. & Aittokallio, T., 1 May 2018, In: Cancer Research. 78, 9, p. 2407-2418 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

      Kauko, O., O’Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, Krister, Narla, G. & Westermarck, J., 18 Jul 2018, In: Science Translational Medicine. 10, 450, p. 1-12 12 p., eaaq1093.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma

      Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. 2019
    93. Published

      Abstract P2-06-25: A phenotypic screening and machine learning platform efficiently identifies triple negative breast cancer-selective and readily druggable targets

      Gautam, P., Jaiswal, A., Aittokallio, T., Hassan, A. & Wennerberg, Krister, 2019, In: Cancer Research. p. P2-06-25-P2-06-25

      Research output: Contribution to journal › Conference abstract in journal › Research

    94. Published

      Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies

      Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Drug screening and molecular profiling identifies INKA1 as a predictive biomarker for sensitivity to MAPK inhibition-antimitotic combination treatment in pancreatic ductal adenocarcinoma

      Gautam, P., Vaha-Koskela, M., Tomlinson, M., Cox, A. D., Der, C. J., Aittokallio, T. & Wennerberg, Krister, 2019, In: Molecular Cancer Therapeutics. 18, 12, A137.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    96. Published

      Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

      Brodin, B. A., Wennerberg, Krister, Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., Von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 2019, In: British Journal of Cancer. 120, 4, p. 435-443 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

      Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets

      Gautam, P., Jaiswal, A., Aittokallio, T., Al-ali, H. & Wennerberg, Krister, 2019, In: Cell Chemical Biology. 26, 7, p. 970-979

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Prediction of drug combination effects with a minimal set of experiments

      Ianevski, A., Giri, A. K., Gautam, P., Kononov, A., Potdar, S., Saarela, J., Wennerberg, Krister & Aittokallio, T., 2019, In: Nature Machine Intelligence. 1, 12, p. 568-577

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

      Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. 2020
    102. Published

      A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening

      Gupta, A., Gautam, P., Wennerberg, Krister & Aittokallio, T., 2020, In: Communications Biology. 3, 1, p. 1-12

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors

      Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, Krister, Hautaniemi, S. & Carpén, O., 2020, In: Journal of Pathology. 250, 2, p. 159-169 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      Abstract P6-10-28: Therapeutic stratification of triple negative breast cancer by integrating chemosensitivity & phospho-proteome profiles

      Gautam, P., Qin, X., Vainonen, J., Nagelli, S., Lampe, J., Klefström, J., Westermarck, J., Wennerberg, Krister & Aittokallio, T., 2020.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    105. Published

      Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer

      Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L. & 8 others, Petricoin, E. F., Simanshu, D. K., Aguirre, A. J., Wolpin, B. M., Wennerberg, Krister, Rudloff, U., Cox, A. D. & Der, C. J., 2020, In: Cancer Discovery. 10, 1, p. 104-123 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Breeze: an integrated quality control and data analysis application for high-throughput drug screening

      Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing

      Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, Krister, Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Published

      Identification of novel regulators of STAT3 activity

      Parri, E., Kuusanmäki, Heikki Aleksi, Van Adrichem, A. J., Kaustio, M. & Wennerberg, Krister, 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics

      Akimov, Y., Bulanova, Daria, Timonen, S., Wennerberg, Krister & Aittokallio, T., 2020, In: Molecular Systems Biology. 16, 3, p. 1-18 e9195.

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. Published

      Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

      Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, Krister, Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220

      Research output: Contribution to journal › Journal article › Research › peer-review

    111. Published

      KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia

      Malani, D., Yadav, B., Kumar, A., Potdar, S., Kontro, M., Kankainen, M., Javarappa, K. K., Porkka, K., Wolf, M., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Murumägi, A. & Kallioniemi, O., 2020, In: Leukemia. 34, p. 2780-2784

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. Published

      Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia

      Kriegbaum, M. C. & Wennerberg, Krister, 2020, In: Cancer Cell. 38, 6, p. 776-778 3 p.

      Research output: Contribution to journal › Journal article › Research

    113. Published

      Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types

      Majumder, M. M., Leppä, A., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O’gorman, P., Wennerberg, Krister, Porkka, K., Gjertsen, B. T. & Heckman, C. A., 2020, In: Haematologica. 105, 6, p. 1527-1538

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. Published

      Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

      Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196

      Research output: Contribution to journal › Journal article › Research › peer-review

    115. Published

      Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1

      Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., Pavic, K., Aakula, A., Rupp, C., Jumppanen, M., Haapaniemi, P., Ruan, L., Yadav, B., Suni, V., Varila, T., Corthals, G. L., Reimand, J., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., 2020, In: Journal of Biological Chemistry. 295, 13, p. 4194-4211

      Research output: Contribution to journal › Journal article › Research › peer-review

    116. Published

      Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

      Hansson, K., Radke, K., Aaltonen, K., Saarela, J., Mañas, A., Sjölund, J., Smith, E. M., Pietras, K., Påhlman, S., Wennerberg, Krister, Gisselsson, D. & Bexell, D., 2020, In: Science Translational Medicine. 12, 562, p. 1-17 eaba4434.

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. 2021
    118. Published

      Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

      White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, Heikki Aleksi, Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, Krister & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.

      Research output: Contribution to journal › Journal article › Research › peer-review

    119. Published

      Crowdsourced mapping of unexplored target space of kinase inhibitors

      Cichonska, A., Ravikumar, B., Allaway, R. J., Wan, F., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C. I., Willson, T. M., Oprea, T. I. & 6 others, Schlessinger, A., Drewry, D. H., Stolovitzky, G., Wennerberg, Krister, Guinney, J. & Aittokallio, T., 2021, In: Nature Communications. 12, 1, 18 p., 3307.

      Research output: Contribution to journal › Journal article › Research › peer-review

    120. Published

      Exploration of databases and methods supporting drug repurposing: A comprehensive survey

      Tanoli, Z., Seemab, U., Scherer, A., Wennerberg, Krister, Tang, J. & Vähä-Koskela, M., 2021, In: Briefings in Bioinformatics. 22, 2, p. 1656-1678 23 p.

      Research output: Contribution to journal › Review › Research › peer-review

    121. Published

      Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

      Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.

      Research output: Contribution to journal › Journal article › Research › peer-review

    122. Published

      Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

      Jaiswal, A., Gautam, P., Pietilä, E. A., Timonen, S., Nordström, N., Akimov, Y., Sipari, N., Tanoli, Z., Fleischer, T., Lehti, K., Wennerberg, Krister & Aittokallio, T., 2021, In: Molecular Systems Biology. 17, 3, p. 1-25 e9526.

      Research output: Contribution to journal › Journal article › Research › peer-review

    123. Published

      Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer

      He, L., Bulanova, Daria, Oikkonen, J., Häkkinen, A., Zhang, K., Zheng, S., Wang, W., Erkan, E. P., Carpén, O., Joutsiniemi, T., Hietanen, S., Hynninen, J., Huhtinen, K., Hautaniemi, S., Vähärautio, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2021, In: Briefings in Bioinformatics. 22, 6, 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    124. Published

      Patient-tailored design for selective co-inhibition of leukemic cell subpopulations

      Ianevski, A., Lahtela, J., Javarappa, K. K., Sergeev, P., Ghimire, B. R., Gautam, P., Vähä-Koskela, M., Turunen, L., Linnavirta, N., Kuusanmäki, Heikki Aleksi, Kontro, M., Porkka, K., Heckman, C. A., Mattila, P., Wennerberg, Krister, Giri, A. K. & Aittokallio, T., 2021, In: Science Advances. 7, 8, eabe4038.

      Research output: Contribution to journal › Journal article › Research › peer-review

    125. Published

      Selective drug combination vulnerabilities in STAT3- And TP53-mutant malignant NK cells

      Parri, E., Kuusanmäki, Heikki Aleksi, Bulanova, Daria, Mustjoki, S. & Wennerberg, Krister, 2021, In: Blood advances. 5, 7, p. 1862-1875

      Research output: Contribution to journal › Journal article › Research › peer-review

    126. 2022
    127. Published

      Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

      Chalabi Hajkarim, M., Karjalainen, E., Osipovitch, M., Dimopoulos, K., Gordon, Sandra, Ambri, F., Rasmussen, K. D., Grønbæk, Kirsten, Helin, K., Wennerberg, Krister & Won, K., 2022, In: eLife. 11, e73760.

      Research output: Contribution to journal › Journal article › Research › peer-review

    128. Published

      Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

      Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, Krister, Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    129. Published

      Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells

      Denisova, O. V., Merisaari, J., Kaur, A., Yetukuri, L., Jumppanen, M., von Schantz-Fant, C., Ohlmeyer, M., Wennerberg, Krister, Aittokallio, T., Taipale, M. & Westermarck, J., 2022, In: Scientific Reports. 12, 9 p., 13796.

      Research output: Contribution to journal › Journal article › Research › peer-review

    130. Published

      Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

      Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, Krister, Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.

      Research output: Contribution to journal › Journal article › Research › peer-review

    131. Published

      Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

      Malani, D., Kumar, A., Brück, O., Kontro, M., Yadav, B., Hellesøy, M., Kuusanmäki, H., Dufva, O., Kankainen, M., Eldfors, S., Potdar, S., Saarela, J., Turunen, L., Parsons, A., Västrik, I., Kivinen, K., Saarela, J., Räty, R., Lehto, M., Wolf, M. & 7 others, Gjertsen, B. T., Mustjoki, S., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Kallioniemi, O. & Porkka, K., 2022, In: Cancer Discovery. 12, 2, p. 388-401 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    132. Published

      Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments

      Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M. D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, Krister, Vähä-Koskela, M. & Tang, J., 2022, In: Briefings in Bioinformatics. 23, 1, 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    133. Published

      Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics

      Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.

      Research output: Contribution to journal › Journal article › Research › peer-review

    134. 2023
    135. Published

      Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia

      Kuusanmäki, H., Kytölä, S., Vänttinen, I., Ruokoranta, T., Ranta, A., Huuhtanen, J., Suvela, M., Parsons, A., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Västrik, I., Dufva, O., Siitonen, S., Porkka, K., Wennerberg, K., Heckman, C. A. & 5 others, Ettala, P., Pyörälä, M., Rimpiläinen, J., Siitonen, T. & Kontro, M., 2023, In: Haematologica. 108, 7, p. 1768-1781 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    136. Published

      A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

      Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, Engelholm, Lars Henning, Christiansen, P., Santoni Rugiu, Eric, Huhtinen, K., Carpén, O., Hynninen, J., Hautaniemi, S., Vähärautio, A. & Wennerberg, Krister, 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    137. Published

      Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data

      Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    138. Published

      Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

      Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I. M., Nygren, P. J., Klievink, J., Bouhlal, J. O. V., Pölönen, P., Zhang, Q., Adnan Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J. J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M. & 9 others, Theilgaard-Mønch, Kim, Wartiovaara-Kautto, U., Keränen, M. A. I., Porkka, K., Konopleva, M., Wennerberg, Krister, Kontro, M., Heckman, C. A. & Mustjoki, S., 2023, In: Blood. 141, 13, p. 1610-1625

      Research output: Contribution to journal › Journal article › Research › peer-review

    139. Published

      PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer

      Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, Krister, 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    140. Published

      PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

      Denisova, O. V., Merisaari, J., Huhtaniemi, R., Qiao, X., Yetukuri, L., Jumppanen, M., Kaur, A., Pääkkönen, M., von Schantz-Fant, С., Ohlmeyer, M., Wennerberg, Krister, Kauko, O., Koch, R., Aittokallio, T., Taipale, M. & Westermarck, J., 2023, In: Molecular Oncology. 17, 9, p. 1803-1820 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    141. Published

      Standardized assays to monitor drug sensitivity in hematologic cancers

      Ayuda-Durán, P., Hermansen, J. U., Giliberto, M., Yin, Y., Hanes, R., Gordon, Sandra, Kuusanmäki, Heikki Aleksi, Brodersen, A. M., Andersen, A. N., Taskén, K., Wennerberg, Krister, Enserink, J. M. & Skånland, S. S., 2023, In: Cell Death Discovery. 9, 13 p., 435.

      Research output: Contribution to journal › Journal article › Research › peer-review

    142. Published

      Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma

      Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.

      Research output: Contribution to journal › Journal article › Research › peer-review

    143. 2024
    144. Published

      Robust scoring of selective drug responses for patient-tailored therapy selection

      Chen, Y., He, L., Ianevski, A., Ayuda-Durán, P., Potdar, S., Saarela, J., Miettinen, J. J., Kytölä, S., Miettinen, S., Manninen, M., Heckman, C. A., Enserink, J. M., Wennerberg, Krister & Aittokallio, T., 2024, In: Nature Protocols. 19, p. 60-82

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 181406515