Krister Wennerberg
Professor
Wennerberg Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- Published
Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
Kuusanmäki, H., Kytölä, S., Vänttinen, I., Ruokoranta, T., Ranta, A., Huuhtanen, J., Suvela, M., Parsons, A., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Västrik, I., Dufva, O., Siitonen, S., Porkka, K., Wennerberg, K., Heckman, C. A. & 5 others, , 2023, In: Haematologica. 108, 7, p. 1768-1781 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines
Broad-DREAM Community, B. C., 22 Nov 2017, In: Cell Systems. 5, 5, p. 485-497.e3Research output: Contribution to journal › Journal article › Research › peer-review
A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis
Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, Krister, Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1644-60 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
A community effort to assess and improve drug sensitivity prediction algorithms
NCI DREAM Community, N. D. C., Dec 2014, In: Nature Biotechnology. 32, 12, p. 1202-12 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
A high-throughput screen for chemical inhibitors of exocytic transport in yeast
Zhang, L., Nebane, N. M., Wennerberg, Krister, Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 Jun 2010, In: ChemBioChem. 11, 9, p. 1291-301 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening
Gupta, A., Gautam, P., Wennerberg, Krister & Aittokallio, T., 2020, In: Communications Biology. 3, 1, p. 1-12Research output: Contribution to journal › Journal article › Research › peer-review
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin
Dubash, A. D., Wennerberg, Krister, García-Mata, R., Menold, M. M., Arthur, W. T. & Burridge, K., 15 Nov 2007, In: Journal of Cell Science. 120, Pt 22, p. 3989-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, , 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury
Kohonen, P., Parkkinen, J. A., Willighagen, E. L., Ceder, R., Wennerberg, Krister, Kaski, S. & Grafström, R. C., 3 Jul 2017, In: Nature Communications. 8, p. 15932Research output: Contribution to journal › Journal article › Research › peer-review
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ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors
Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, Krister, Hautaniemi, S. & Carpén, O., 2020, In: Journal of Pathology. 250, 2, p. 159-169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Abstract P2-06-25: A phenotypic screening and machine learning platform efficiently identifies triple negative breast cancer-selective and readily druggable targets
Gautam, P., Jaiswal, A., Aittokallio, T., Hassan, A. & Wennerberg, Krister, 2019, In: Cancer Research. p. P2-06-25-P2-06-25Research output: Contribution to journal › Conference abstract in journal › Research
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Abstract P6-10-28: Therapeutic stratification of triple negative breast cancer by integrating chemosensitivity & phospho-proteome profiles
Gautam, P., Qin, X., Vainonen, J., Nagelli, S., Lampe, J., Klefström, J., Westermarck, J., Wennerberg, Krister & Aittokallio, T., 2020.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Analysis of activated GAPs and GEFs in cell lysates
García-Mata, R., Wennerberg, Krister, Arthur, W. T., Noren, N. K., Ellerbroek, S. M. & Burridge, K., 2006, In: Methods in Enzymology. 406, p. 425-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Antifungal application of nonantifungal drugs
Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer
Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L. & 8 others, , 2020, In: Cancer Discovery. 10, 1, p. 104-123 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia
White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, Heikki Aleksi, Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, Krister & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.Research output: Contribution to journal › Journal article › Research › peer-review
Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening
Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening
Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, Krister & Vidugiriene, J., Oct 2015, In: ASSAY and Drug Development Technologies. 13, 8, p. 456-65 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Breeze: an integrated quality control and data analysis application for high-throughput drug screening
Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604Research output: Contribution to journal › Journal article › Research › peer-review
Cancer Cell Drug Response Transcriptomes in 3D
Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies
Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622Research output: Contribution to journal › Journal article › Research › peer-review
Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer
Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models
Chalabi Hajkarim, M., Karjalainen, E., Osipovitch, M., Dimopoulos, K., Gordon, Sandra, Ambri, F., Rasmussen, K. D., Grønbæk, Kirsten, Helin, K., Wennerberg, Krister & Won, K., 2022, In: eLife. 11, e73760.Research output: Contribution to journal › Journal article › Research › peer-review
Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs
Khan, S. A., Faisal, A., Mpindi, J. P., Parkkinen, J. A., Kalliokoski, T., Poso, A., Kallioniemi, O. P., Wennerberg, Krister & Kaski, S., 30 May 2012, In: BMC Bioinformatics. 13, p. 112Research output: Contribution to journal › Journal article › Research › peer-review
Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
Cichonska, A., Ravikumar, B., Parri, E., Timonen, S., Pahikkala, T., Airola, A., Wennerberg, Krister, Rousu, J. & Aittokallio, T., Aug 2017, In: PLOS Computational Biology. 13, 8, p. e1005678Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, Krister, Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Consistency in drug response profiling
Mpindi, J. P., Yadav, B., Östling, P., Gautam, P., Malani, D., Murumägi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, Krister, Kallioniemi, O. & Aittokallio, T., 30 Nov 2016, In: Nature. 540, 7631, p. E5-E6Research output: Contribution to journal › Journal article › Research › peer-review
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Crowdsourced mapping of unexplored target space of kinase inhibitors
Cichonska, A., Ravikumar, B., Allaway, R. J., Wan, F., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C. I., Willson, T. M., Oprea, T. I. & 6 others, , 2021, In: Nature Communications. 12, 1, 18 p., 3307.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells
Denisova, O. V., Merisaari, J., Kaur, A., Yetukuri, L., Jumppanen, M., von Schantz-Fant, C., Ohlmeyer, M., Wennerberg, Krister, Aittokallio, T., Taipale, M. & Westermarck, J., 2022, In: Scientific Reports. 12, 9 p., 13796.Research output: Contribution to journal › Journal article › Research › peer-review
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP
van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses
Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, , 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2Research output: Contribution to journal › Journal article › Research › peer-review
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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.Research output: Contribution to journal › Journal article › Research › peer-review
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Drug screening and molecular profiling identifies INKA1 as a predictive biomarker for sensitivity to MAPK inhibition-antimitotic combination treatment in pancreatic ductal adenocarcinoma
Gautam, P., Vaha-Koskela, M., Tomlinson, M., Cox, A. D., Der, C. J., Aittokallio, T. & Wennerberg, Krister, 2019, In: Molecular Cancer Therapeutics. 18, 12, A137.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, Krister, Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In: OncoTarget. 8, 57, p. 97516-97527 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas
Brodin, B. A., Wennerberg, Krister, Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., Von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 2019, In: British Journal of Cancer. 120, 4, p. 435-443 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy
Lepikhova, T., Karhemo, P. R., Louhimo, R., Yadav, B., Murumagi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjanen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, Krister, Joensuu, H. & Monni, O., 2018, In: Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status
Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, Krister, Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.Research output: Contribution to journal › Journal article › Research › peer-review
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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I. M., Nygren, P. J., Klievink, J., Bouhlal, J. O. V., Pölönen, P., Zhang, Q., Adnan Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J. J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M. & 9 others, , 2023, In: Blood. 141, 13, p. 1610-1625Research output: Contribution to journal › Journal article › Research › peer-review
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Exploration of databases and methods supporting drug repurposing: A comprehensive survey
Tanoli, Z., Seemab, U., Scherer, A., Wennerberg, Krister, Tang, J. & Vähä-Koskela, M., 2021, In: Briefings in Bioinformatics. 22, 2, p. 1656-1678 23 p.Research output: Contribution to journal › Review › Research › peer-review
From drug response profiling to target addiction scoring in cancer cell models
Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.Research output: Contribution to journal › Journal article › Research › peer-review
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Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza
Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, Krister & Noah, J. W., Jul 2014, In: Journal of Biomolecular Screening. 19, 6, p. 936-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach
Ali, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Apr 2018, In: Bioinformatics (Online). 34, 8, p. 1353-1362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
High-Throughput Dual Screening Method for Ras Activities and Inhibitors
Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, Krister & Härmä, H., 18 Apr 2017, In: Analytical Chemistry. 89, 8, p. 4508-4516 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 181406515
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Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Research output: Contribution to journal › Journal article › Research › peer-review
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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
Research output: Contribution to journal › Journal article › Research › peer-review
Published