Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
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Breeze 2.0 : an interactive web-tool for visual analysis and comparison of drug response data. / Potdar, Swapnil; Ianevski, Filipp; Ianevski, Aleksandr; Tanoli, Ziaurrehman; Wennerberg, Krister; Seashore-Ludlow, Brinton; Kallioniemi, Olli; Ostling, Paivi; Aittokallio, Tero; Saarela, Jani.
In: Nucleic Acids Research, Vol. 51, No. W1, 2023, p. W57-W61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Breeze 2.0
T2 - an interactive web-tool for visual analysis and comparison of drug response data
AU - Potdar, Swapnil
AU - Ianevski, Filipp
AU - Ianevski, Aleksandr
AU - Tanoli, Ziaurrehman
AU - Wennerberg, Krister
AU - Seashore-Ludlow, Brinton
AU - Kallioniemi, Olli
AU - Ostling, Paivi
AU - Aittokallio, Tero
AU - Saarela, Jani
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2023
Y1 - 2023
N2 - Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy and reliability of the results are critical. In response to this need, we previously developed Breeze, a drug screening data analysis pipeline, designed to facilitate quality control, dose-response curve fitting, and data visualization in a user-friendly manner. Here, we describe the latest version of Breeze (release 2.0), which implements an array of advanced data exploration capabilities, providing users with comprehensive post-analysis and interactive visualization options that are essential for minimizing false positive/negative outcomes and ensuring accurate interpretation of drug sensitivity and resistance data. The Breeze 2.0 web-tool also enables integrative analysis and cross-comparison of user-uploaded data with publicly available drug response datasets. The updated version incorporates new drug quantification metrics, supports analysis of both multi-dose and single-dose drug screening data and introduces a redesigned, intuitive user interface. With these enhancements, Breeze 2.0 is anticipated to substantially broaden its potential applications in diverse domains of fPM.
AB - Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy and reliability of the results are critical. In response to this need, we previously developed Breeze, a drug screening data analysis pipeline, designed to facilitate quality control, dose-response curve fitting, and data visualization in a user-friendly manner. Here, we describe the latest version of Breeze (release 2.0), which implements an array of advanced data exploration capabilities, providing users with comprehensive post-analysis and interactive visualization options that are essential for minimizing false positive/negative outcomes and ensuring accurate interpretation of drug sensitivity and resistance data. The Breeze 2.0 web-tool also enables integrative analysis and cross-comparison of user-uploaded data with publicly available drug response datasets. The updated version incorporates new drug quantification metrics, supports analysis of both multi-dose and single-dose drug screening data and introduces a redesigned, intuitive user interface. With these enhancements, Breeze 2.0 is anticipated to substantially broaden its potential applications in diverse domains of fPM.
U2 - 10.1093/nar/gkad390
DO - 10.1093/nar/gkad390
M3 - Journal article
C2 - 37178002
AN - SCOPUS:85163938249
VL - 51
SP - W57-W61
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - W1
ER -
ID: 360402762