Claus Storgaard Sørensen

Claus Storgaard Sørensen

Associate Professor, Professor

Member of:

    ORCID: 0000-0001-6022-9710

    Publication year:
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    1 - 50 out of 72Page size: 50
    1. 2024
    2. Published

      PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling

      Tuppurainen, H., Laurila, N., Nätynki, M., Eshraghi, L., Tervasmäki, A., Erichsen, L., Sørensen, Claus Storgaard, Pylkäs, K., Winqvist, R. & Peltoketo, H., 2024, In: Cellular and Molecular Life Sciences. 81, 21 p., 173.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2023
    4. Published

      ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

      Piotrowski, Kris, Puig Blasco, Laia, Samsøe-Petersen, Jacob, Eefsen, R. L., Illemann, M., Oria, Victor Oginga, Campos, K. I. A., Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, X. F., Kveiborg, Marie & Gnosa, S., 2023, In: Cancer Gene Therapy. 30, p. 1369-1381 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation

      Kwon, Y., Rösner, H., Zhao, W., Selemenakis, P., He, Z., Kawale, A. S., Katz, J. N., Rogers, C. M., Neal, F. E., Badamchi Shabestari, A., Petrosius, V., Singh, A. K., Joel, M. Z., Lu, L., Holloway, S. P., Burma, S., Mukherjee, B., Hromas, R., Mazin, A., Wiese, C. & 2 others, Sørensen, Claus Storgaard & Sung, P., 2023, In: Nature Communications. 14, 18 p., 432.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

      Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, Hodek, O., Homan, E., Bonagas, N., Ramos, L., Sandberg, L., Frödin, Morten, Moussay, E., Slipicevic, A., Letellier, E., Paggetti, J., Sørensen, Claus Storgaard, Helleday, T., Henriksson, M. & Meiser, J., 2023, In: Nature Metabolism. 5, p. 642-659

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Self-inflicted DNA breaks in cell differentiation and cancer

      Benada, Jan, Alsowaida, D., Megeney, L. A. & Sørensen, Claus Storgaard, 2023, In: Trends in Cell Biology. 33, 10, p. 850-859

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma

      Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

      Petrosius, V., Benada, Jan, Nielsen, Olaf, Schoof, E. M. & Sørensen, Claus Storgaard, 2023, In: iScience. 26, 1, 24 p., 105806.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2022
    11. Published

      A catalog of curated breast cancer genes

      Bose, M., Benada, Jan, Thatte, Jayashree Vijay, Kinalis, S., Ejlertsen, Bent Laursen, Nielsen, Finn Cilius, Sørensen, Claus Storgaard & Rossing, Caroline Maria, 2022, In: Breast Cancer Research and Treatment. 191, p. 431-441

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress

      Larsen, Brian Daniel, Benada, Jan, Yung, P. Y. K., Bell, R. A. V., Pappas, G., Urban, V., Ahlskog, J. K., Kuo, T. T., Janscak, P., Megeney, L. A., Elsässer, S. J., Bartek, J. & Sørensen, Claus Storgaard, 2022, In: Science. 376, 6592, p. 476-483 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway

      Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

      Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

      Elbæk, C. R., Petrosius, V., Benada, Jan, Erichsen, L., Damgaard, R. B. & Sørensen, Claus Storgaard, 2022, In: Cell Reports. 38, 3, 110261.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. 2021
    17. Published

      Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

      Shoaib, Muhammad, Chen, Q., Shi, X., Nair, Nidhi, Prasanna, C., Yang, R., Walter, D., Frederiksen, K. S., Einarsson, H., Svensson, J. P., Liu, C. F., Ekwall, K., Lerdrup, Mads, Nordenskiöld, L. & Sørensen, Claus Storgaard, 2021, In: Nature Communications. 12, 1, 16 p., 4800.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2020
    19. Published

      Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

      Zarrizi, R., Higgs, M. R., Voßgröne, Karolin, Rossing, M., Bertelsen, B., Bose, M., Kousholt, A. N., Rösner, Heike Ilona, Network, T. C., Ejlertsen, Bent Laursen, Stewart, G. S., Nielsen, Finn Cilius & Sørensen, Claus Storgaard, 3 Aug 2020, In: The Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse

      Ercilla, A., Feu, S., Aranda, S., Llopis, A., Brynjólfsdóttir, S. H., Sørensen, Claus Storgaard, Toledo, L. I. & Agell, N., 2020, In: Cellular and molecular life sciences : CMLS. 77, p. 735–749

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Chromatin Landscaping At Mitotic Exit Orchestrates Genome Function

      Shoaib, Muhammad, Nair, Nidhi & Sørensen, Claus Storgaard, 2020, In: Frontiers in Genetics. 11, p. 1-9 103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Photochemotherapy Induces Interferon Type III Expression via STING Pathway

      Biskup, E., Larsen, Brian Daniel, Rib, Leonor, Folkersen, L., Niazi, O., Kamstrup, M. R. & Sørensen, Claus Storgaard, 2020, In: Cells. 9, 11, p. 1-19

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry

      Elbæk, C. R., Petrosius, V. & Sørensen, Claus Storgaard, 2020, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 819-820, p. 1-6 6 p., 111694.

      Research output: Contribution to journal › Review › Research › peer-review

    24. 2019
    25. Published

      E2F transcription regulation: an orphan cyclin enters the stage

      Rösner, Heike Ilona & Sørensen, Claus Storgaard, 2019, In: The EMBO Journal. 38, 20, e103421.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Overcoming Treatment Toxicity through Sequential Therapy

      Benada, Jan, Ejlertsen, Bent Laursen & Sørensen, Claus Storgaard, 2019, In: Cancer Cell. 35, 6, p. 821-822 2 p.

      Research output: Contribution to journal › Journal article › Research

    27. Published

      PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

      Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, Claus Storgaard, Oakley, G. G., Ganesan, S., Bunting, S. F. & Xia, B., 2019, In: Oncogene. 38, p. 1585–1596

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Whole genome sequencing of breast cancer

      Rossing, M., Sørensen, Claus Storgaard, Ejlertsen, Bent Laursen & Nielsen, Finn Cilius, 2019, In: APMIS - Journal of Pathology, Microbiology and Immunology. 127, 5, p. 303-315 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    29. 2018
    30. Published

      Hereditary risk of breast and ovarian cancer: BRCA1 and BRCA2

      Sørensen, Claus Storgaard, 1 Jan 2018, Encyclopedia of Cancer. Elsevier, p. 214-217 4 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    31. Published

      Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

      Shoaib, Muhammad, Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, K., Julien, E., Blow, J. J. & Sørensen, Claus Storgaard, 2018, In: Nature Communications. 9, 1, p. 1-11 11 p., 3704.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

      Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, Gorgoulis, V. G., 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains

      Jurisic, A., Robin, C., Tarlykov, P., Siggens, L., Schoell, B., Jauch, A., Ekwall, K., Sørensen, Claus Storgaard, Lipinski, M., Shoaib, Muhammad & Ogryzko, V., 2018, In: Nucleic Acids Research. 46, 22, p. 1-16 16 p., e135.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. 2017
    35. Published

      Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

      Nair, Nidhi, Shoaib, Muhammad & Sørensen, Claus Storgaard, 10 Jul 2017, In: International Journal of Molecular Sciences. 18, 7, 21 p., 1486.

      Research output: Contribution to journal › Review › Research › peer-review

    36. Published

      The caspase-activated DNase: apoptosis and beyond

      Larsen, Brian Daniel & Sørensen, Claus Storgaard, Apr 2017, In: F E B S Journal. 284, 8, p. 1160-1170 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    37. 2016
    38. Published

      Hereditary breast and ovarian cancer: new genes in confined pathways

      Nielsen, Finn Cilius, Hansen, T. V. O. & Sørensen, Claus Storgaard, Sep 2016, In: Nature Reviews. Cancer. 16, 9, p. 599-612 14 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. Published

      Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

      Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F-M., Gagos, S., Tzetis, M., Canovas, B., Igea, A., Ahuja, A. K., Zellweger, R., Havaki, S., Kanavakis, E., Kletsas, D., Roninson, I. B., Garbis, S. D., Lopes, M. & 7 others, Nebreda, A., Thanos, D., Blow, J. J., Townsend, P., Sørensen, Claus Storgaard, Bartek, J. & Gorgoulis, V. G., Jul 2016, In: Nature Cell Biology. 18, 7, p. 777-89 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities

      Boyer, A., Walter, D. & Sørensen, Claus Storgaard, Jun 2016, In: Seminars in Cancer Biology. 37-38, p. 16-25 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    41. Published

      ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function

      Ahlskog, J. K., Larsen, Brian Daniel, Achanta, K. & Sørensen, Claus Storgaard, May 2016, In: E M B O Reports. 17, 5, p. 671-81 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis

      Burkovics, P., Dome, L., Juhasz, S., Altmannova, V., Sebesta, M., Pacesa, M., Fugger, K., Sørensen, Claus Storgaard, Lee, M. Y. W. T., Haracska, L. & Krejci, L., 20 Apr 2016, In: Nucleic Acids Research. 44, 7, p. 3176-89 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

      Walter, D., Hoffmann, Saskia, Komseli, E., Rappsilber, J., Gorgoulis, V. & Sørensen, Claus Storgaard, 2016, In: Nature Communications. 7, 10 p., 10530.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2015
    45. Published

      Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

      Shoaib, Muhammad & Sørensen, Claus Storgaard, 9 Nov 2015, In: Cancer Cell. 28, 5, p. 545-547 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      FBH1: a new checkpoint factor

      Boyer, A. & Sørensen, Claus Storgaard, 14 Aug 2015, In: OncoTarget. 6, 23, p. 19354-19355 2 p.

      Research output: Contribution to journal › Editorial › Research › peer-review

    47. Published

      Exploiting replicative stress to treat cancer

      Dobbelstein, M. & Sørensen, Claus Storgaard, Jun 2015, In: Nature Reviews. Drug Discovery. 14, 6, p. 405-23 19 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      FBH1 Catalyzes Regression of Stalled Replication Forks

      Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control

      Klein, D. K., Hoffmann, Saskia, Ahlskog, J. K., O'Hanlon, K., Quaas, M., Larsen, Brian Daniel, Rolland, B., Rösner, Heike Ilona, Walter, D., Kousholt, A. N., Menzel, T., Lees, M., Johansen, Jens Vilstrup, Rappsilber, J., Engeland, K. & Sørensen, Claus Storgaard, 2015, In: Nature Communications. 6, p. 5800

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP

      Hühn, D., Kousholt, A. N., Sørensen, Claus Storgaard & Sartori, A. A., 2015, In: Oncogene. 0, p. 3977-3984 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2013
    52. Published

      Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

      Köpper, F., Bierwirth, C., Schön, M., Kunze, M., Elvers, I., Kranz, D., Saini, P., Menon, M. B., Walter, D., Sørensen, Claus Storgaard, Gaestel, M., Helleday, T., Schön, M. P. & Dobbelstein, M., 15 Oct 2013, In: PNAS Early Edition. 110, 42, p. 16856-61 6 p.

      Research output: Contribution to journal › Journal article › Research

    53. Published

      Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

      Jørgensen, S., Schotta, G. & Sørensen, Claus Storgaard, 1 Mar 2013, In: Nucleic Acids Research. 41, 5, p. 2797-806 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

      Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. 2012
    56. Published

      LEDGF (p75) promotes DNA-end resection and homologous recombination

      Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, Claus Storgaard, Petersen, N. H. T., Sorensen, P. H. B., Lukas, Claudia, Bartek, J., Lukas, Jiri, Rohde, M. & Jaattela, Marja, Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Pathways for genome integrity in G2 phase of the cell cycle

      Kousholt, A. N., Menzel, T. & Sørensen, Claus Storgaard, 1 Jan 2012, In: Biomolecules. 2, 4, p. 579-607 29 p.

      Research output: Contribution to journal › Review › Research › peer-review

    58. Published

      CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

      Kousholt, A. N., Fugger, K., Hoffmann, S., Larsen, Brian Daniel, Menzel, T., Sartori, A. A. & Sørensen, Claus Storgaard, 2012, In: Journal of Cell Biology. 197, 7, p. 869-76 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption

      Beck, H., Nähse-Kumpf, V., Larsen, Marie Sofie Yoo, O'Hanlon, K. A., Patzke, S., Holmberg, Christian, Mejlvang, J., Groth, Anja, Nielsen, Olaf, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 2012, In: Molecular and Cellular Biology. 32, 20, p. 4226-4236 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

      Sørensen, Claus Storgaard & Syljuåsen, R. G., 2012, In: Nucleic Acids Research. 40, 2, p. 477-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. 2011
    62. Published

      SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

      Jørgensen, S., Eskildsen, M., Fugger, K., Hansen, L., Larsen, Marie Sofie Yoo, Kousholt, A. N., Syljuåsen, R. G., Trelle, M. B., Jensen, O. N., Helin, K. & Sørensen, Claus Storgaard, 10 Jan 2011, In: Journal of Cell Biology. 192, 1, p. 43-54 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

      Menzel, T., Nähse-Kumpf, V., Kousholt, A. N., Klein, D. K., Lund-Andersen, C., Lees, M., Johansen, Jens Vilstrup, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 1 Jan 2011, In: E M B O Reports. 12, 7, p. 705-12 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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