Claus Storgaard Sørensen
Associate Professor, Professor
Sørensen Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- 2024
- Published
PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
Tuppurainen, H., Laurila, N., Nätynki, M., Eshraghi, L., Tervasmäki, A., Erichsen, L., Sørensen, Claus Storgaard, Pylkäs, K., Winqvist, R. & Peltoketo, H., 2024, In: Cellular and Molecular Life Sciences. 81, 21 p., 173.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Self-inflicted DNA breaks in cell differentiation and cancer
Benada, Jan, Alsowaida, D., Megeney, L. A. & Sørensen, Claus Storgaard, 2023, In: Trends in Cell Biology. 33, 10, p. 850-859Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma
Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, , 2023, In: Nature Metabolism. 5, p. 642-659Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation
Kwon, Y., Rösner, H., Zhao, W., Selemenakis, P., He, Z., Kawale, A. S., Katz, J. N., Rogers, C. M., Neal, F. E., Badamchi Shabestari, A., Petrosius, V., Singh, A. K., Joel, M. Z., Lu, L., Holloway, S. P., Burma, S., Mukherjee, B., Hromas, R., Mazin, A., Wiese, C. & 2 others, , 2023, In: Nature Communications. 14, 18 p., 432.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
Petrosius, V., Benada, Jan, Nielsen, Olaf, Schoof, E. M. & Sørensen, Claus Storgaard, 2023, In: iScience. 26, 1, 24 p., 105806.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy
Piotrowski, Kris, Puig Blasco, Laia, Samsøe-Petersen, Jacob, Eefsen, R. L., Illemann, M., Oria, Victor Oginga, Campos, K. I. A., Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, X. F., Kveiborg, Marie & Gnosa, S., 2023, In: Cancer Gene Therapy. 30, p. 1369-1381 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A catalog of curated breast cancer genes
Bose, M., Benada, Jan, Thatte, Jayashree Vijay, Kinalis, S., Ejlertsen, Bent Laursen, Nielsen, Finn Cilius, Sørensen, Claus Storgaard & Rossing, Caroline Maria, 2022, In: Breast Cancer Research and Treatment. 191, p. 431-441Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
Elbæk, C. R., Petrosius, V., Benada, Jan, Erichsen, L., Damgaard, R. B. & Sørensen, Claus Storgaard, 2022, In: Cell Reports. 38, 3, 110261.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
Larsen, Brian Daniel, Benada, Jan, Yung, P. Y. K., Bell, R. A. V., Pappas, G., Urban, V., Ahlskog, J. K., Kuo, T. T., Janscak, P., Megeney, L. A., Elsässer, S. J., Bartek, J. & Sørensen, Claus Storgaard, 2022, In: Science. 376, 6592, p. 476-483 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway
Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
Shoaib, Muhammad, Chen, Q., Shi, X., Nair, Nidhi, Prasanna, C., Yang, R., Walter, D., Frederiksen, K. S., Einarsson, H., Svensson, J. P., Liu, C. F., Ekwall, K., Lerdrup, Mads, Nordenskiöld, L. & Sørensen, Claus Storgaard, 2021, In: Nature Communications. 12, 1, 16 p., 4800.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Photochemotherapy Induces Interferon Type III Expression via STING Pathway
Biskup, E., Larsen, Brian Daniel, Rib, Leonor, Folkersen, L., Niazi, O., Kamstrup, M. R. & Sørensen, Claus Storgaard, 2020, In: Cells. 9, 11, p. 1-19Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry
Elbæk, C. R., Petrosius, V. & Sørensen, Claus Storgaard, 2020, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 819-820, p. 1-6 6 p., 111694.Research output: Contribution to journal › Review › Research › peer-review
- Published
Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse
Ercilla, A., Feu, S., Aranda, S., Llopis, A., Brynjólfsdóttir, S. H., Sørensen, Claus Storgaard, Toledo, L. I. & Agell, N., 2020, In: Cellular and molecular life sciences : CMLS. 77, p. 735–749Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromatin Landscaping At Mitotic Exit Orchestrates Genome Function
Shoaib, Muhammad, Nair, Nidhi & Sørensen, Claus Storgaard, 2020, In: Frontiers in Genetics. 11, p. 1-9 103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability
Zarrizi, R., Higgs, M. R., Voßgröne, Karolin, Rossing, M., Bertelsen, B., Bose, M., Kousholt, A. N., Rösner, Heike Ilona, Network, T. C., Ejlertsen, Bent Laursen, Stewart, G. S., Nielsen, Finn Cilius & Sørensen, Claus Storgaard, 3 Aug 2020, In: The Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Overcoming Treatment Toxicity through Sequential Therapy
Benada, Jan, Ejlertsen, Bent Laursen & Sørensen, Claus Storgaard, 2019, In: Cancer Cell. 35, 6, p. 821-822 2 p.Research output: Contribution to journal › Journal article › Research
- Published
Whole genome sequencing of breast cancer
Rossing, M., Sørensen, Claus Storgaard, Ejlertsen, Bent Laursen & Nielsen, Finn Cilius, 2019, In: APMIS - Journal of Pathology, Microbiology and Immunology. 127, 5, p. 303-315 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
E2F transcription regulation: an orphan cyclin enters the stage
Rösner, Heike Ilona & Sørensen, Claus Storgaard, 2019, In: The EMBO Journal. 38, 20, e103421.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response
Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, Claus Storgaard, Oakley, G. G., Ganesan, S., Bunting, S. F. & Xia, B., 2019, In: Oncogene. 38, p. 1585–1596Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, , 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains
Jurisic, A., Robin, C., Tarlykov, P., Siggens, L., Schoell, B., Jauch, A., Ekwall, K., Sørensen, Claus Storgaard, Lipinski, M., Shoaib, Muhammad & Ogryzko, V., 2018, In: Nucleic Acids Research. 46, 22, p. 1-16 16 p., e135.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
Shoaib, Muhammad, Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, K., Julien, E., Blow, J. J. & Sørensen, Claus Storgaard, 2018, In: Nature Communications. 9, 1, p. 1-11 11 p., 3704.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hereditary risk of breast and ovarian cancer: BRCA1 and BRCA2
Sørensen, Claus Storgaard, 1 Jan 2018, Encyclopedia of Cancer. Elsevier, p. 214-217 4 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2017
- Published
The caspase-activated DNase: apoptosis and beyond
Larsen, Brian Daniel & Sørensen, Claus Storgaard, Apr 2017, In: F E B S Journal. 284, 8, p. 1160-1170 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair
Nair, Nidhi, Shoaib, Muhammad & Sørensen, Claus Storgaard, 10 Jul 2017, In: International Journal of Molecular Sciences. 18, 7, 21 p., 1486.Research output: Contribution to journal › Review › Research › peer-review
- 2016
- Published
ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function
Ahlskog, J. K., Larsen, Brian Daniel, Achanta, K. & Sørensen, Claus Storgaard, May 2016, In: E M B O Reports. 17, 5, p. 671-81 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities
Boyer, A., Walter, D. & Sørensen, Claus Storgaard, Jun 2016, In: Seminars in Cancer Biology. 37-38, p. 16-25 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis
Burkovics, P., Dome, L., Juhasz, S., Altmannova, V., Sebesta, M., Pacesa, M., Fugger, K., Sørensen, Claus Storgaard, Lee, M. Y. W. T., Haracska, L. & Krejci, L., 20 Apr 2016, In: Nucleic Acids Research. 44, 7, p. 3176-89 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F-M., Gagos, S., Tzetis, M., Canovas, B., Igea, A., Ahuja, A. K., Zellweger, R., Havaki, S., Kanavakis, E., Kletsas, D., Roninson, I. B., Garbis, S. D., Lopes, M. & 7 others, , Jul 2016, In: Nature Cell Biology. 18, 7, p. 777-89 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hereditary breast and ovarian cancer: new genes in confined pathways
Nielsen, Finn Cilius, Hansen, T. V. O. & Sørensen, Claus Storgaard, Sep 2016, In: Nature Reviews. Cancer. 16, 9, p. 599-612 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
Walter, D., Hoffmann, Saskia, Komseli, E., Rappsilber, J., Gorgoulis, V. & Sørensen, Claus Storgaard, 2016, In: Nature Communications. 7, 10 p., 10530.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
FBH1: a new checkpoint factor
Boyer, A. & Sørensen, Claus Storgaard, 14 Aug 2015, In: OncoTarget. 6, 23, p. 19354-19355 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Exploiting replicative stress to treat cancer
Dobbelstein, M. & Sørensen, Claus Storgaard, Jun 2015, In: Nature Reviews. Drug Discovery. 14, 6, p. 405-23 19 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
FBH1 Catalyzes Regression of Stalled Replication Forks
Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP
Hühn, D., Kousholt, A. N., Sørensen, Claus Storgaard & Sartori, A. A., 2015, In: Oncogene. 0, p. 3977-3984 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control
Klein, D. K., Hoffmann, Saskia, Ahlskog, J. K., O'Hanlon, K., Quaas, M., Larsen, Brian Daniel, Rolland, B., Rösner, Heike Ilona, Walter, D., Kousholt, A. N., Menzel, T., Lees, M., Johansen, Jens Vilstrup, Rappsilber, J., Engeland, K. & Sørensen, Claus Storgaard, 2015, In: Nature Communications. 6, p. 5800Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave
Shoaib, Muhammad & Sørensen, Claus Storgaard, 9 Nov 2015, In: Cancer Cell. 28, 5, p. 545-547 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress
Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Jørgensen, S., Schotta, G. & Sørensen, Claus Storgaard, 1 Mar 2013, In: Nucleic Acids Research. 41, 5, p. 2797-806 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Köpper, F., Bierwirth, C., Schön, M., Kunze, M., Elvers, I., Kranz, D., Saini, P., Menon, M. B., Walter, D., Sørensen, Claus Storgaard, Gaestel, M., Helleday, T., Schön, M. P. & Dobbelstein, M., 15 Oct 2013, In: PNAS Early Edition. 110, 42, p. 16856-61 6 p.Research output: Contribution to journal › Journal article › Research
- 2012
- Published
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Beck, H., Nähse-Kumpf, V., Larsen, Marie Sofie Yoo, O'Hanlon, K. A., Patzke, S., Holmberg, Christian, Mejlvang, J., Groth, Anja, Nielsen, Olaf, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 2012, In: Molecular and Cellular Biology. 32, 20, p. 4226-4236 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LEDGF (p75) promotes DNA-end resection and homologous recombination
Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, Claus Storgaard, Petersen, N. H. T., Sorensen, P. H. B., Lukas, Claudia, Bartek, J., Lukas, Jiri, Rohde, M. & Jaattela, Marja, Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
Kousholt, A. N., Fugger, K., Hoffmann, S., Larsen, Brian Daniel, Menzel, T., Sartori, A. A. & Sørensen, Claus Storgaard, 2012, In: Journal of Cell Biology. 197, 7, p. 869-76 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathways for genome integrity in G2 phase of the cell cycle
Kousholt, A. N., Menzel, T. & Sørensen, Claus Storgaard, 1 Jan 2012, In: Biomolecules. 2, 4, p. 579-607 29 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
Sørensen, Claus Storgaard & Syljuåsen, R. G., 2012, In: Nucleic Acids Research. 40, 2, p. 477-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
Jørgensen, S., Eskildsen, M., Fugger, K., Hansen, L., Larsen, Marie Sofie Yoo, Kousholt, A. N., Syljuåsen, R. G., Trelle, M. B., Jensen, O. N., Helin, K. & Sørensen, Claus Storgaard, 10 Jan 2011, In: Journal of Cell Biology. 192, 1, p. 43-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
Menzel, T., Nähse-Kumpf, V., Kousholt, A. N., Klein, D. K., Lund-Andersen, C., Lees, M., Johansen, Jens Vilstrup, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 1 Jan 2011, In: E M B O Reports. 12, 7, p. 705-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 10867
Most downloads
-
338
downloads
Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair
Research output: Contribution to journal › Review › Research › peer-review
Published -
244
downloads
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
175
downloads
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Research output: Contribution to journal › Journal article › Research › peer-review
Published