Michael Ploug

Michael Ploug

Group leader

ORCID: 0000-0003-2215-4265

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  1. Published

    Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit

    Liu, M., Hansen, G. H., Ploug, Michael, Hanlin, L., Jiang, L., Yuan, C., Li, J. & Huang, M., 2019, In: FEBS Letters. 593, 11, p. 1236-1247 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

    Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Peptide disc mediated control of membrane protein orientation in supported lipid bilayers for surface-sensitive investigations

    Luchini, A., Tidemand, Frederik Grønbæk, Johansen, Nicolai Tidemand, Campana, M., Sotres, J., Ploug, Michael, Cárdenas, M. & Arleth, Lise, 2019, In: Analytical Chemistry. 92, 1, p. 1081-1088

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice

    Lund, L. R., Green, K. A., Stoop, A. A., Ploug, Michael, Almholt, K., Lilla, J., Nielsen, B. S., Christensen, I. J., Craik, C. S., Werb, Z., Danø, K. & Rømer, J., 2006, In: EMBO Journal. 25, 12, p. 2686-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

    Winther, Anne-Marie Lund, Kumari, Anni, Young, S. G. & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 2 p., 100071.

    Research output: Contribution to journal › Comment/debate › Research

  6. Published

    Expression and one-step purification of active LPL contemplated by biophysical considerations

    Winther, Anne-Marie Lund, Kristensen, Kristian Kølby, Kumari, Anni & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 13 p., 100149.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report

    Lutz, J., Dunaj-Kazmierowska, M., Arcan, S., Kassner, U., Miyashita, K., Murakami, M., Ploug, Michael, Fong, L. G., Young, S. G., Nakajima, K. & Beigneux, A. P., 2020, In: Annals of Internal Medicine. 173, 9, p. 764-765

    Research output: Contribution to journal › Letter › Research › peer-review

  8. Published

    The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

    Luz, J., Beigneux, A. P., Asamoto, D. K., He, C., Song, W., Allan, C. M., Morales, J. E., Tu, Y., Kwok, A., Cottle, T., Meiyappan, M., Fong, L. G., Kim, J., Ploug, Michael, Young, S. G. & Birrane, G., 2020, In: Journal of Lipid Research. 61, 10, p. 1347-1359

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

    Metrangolo, Virginia, Ploug, Michael & Engelholm, Lars Henning, 2021, In: Cancers. 13, 21, 45 p., 5376.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum

    Miyashita, K., Fukamachi, I., Nagao, M., Ishida, T., Kobayashi, J., Machida, T., Nakajima, K., Murakami, M., Ploug, Michael, Beigneux, A. P., Young, S. G. & Nakajima, K., Jan 2018, In: Journal of Clinical Lipidology. 12, 1, p. 203-210 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Chylomicronemia from GPIHBP1 autoantibodies

    Miyashita, K., Lutz, J., Hudgins, L. C., Toib, D., Ashraf, A. P., Song, W., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Lipid Research. 61, 11, p. 1365-1376

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Mysling, S., Kristensen, K. K., Larsson, M., Kovrov, O., Bensadouen, A., Jørgensen, T. J. D., Olivecrona, G., Young, S. G. & Ploug, Michael, 8 Dec 2016, In: eLife. 5, 18 p., e20958.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

    Mysling, S., Salbo, R., Ploug, Michael & Jørgensen, T. J. D., 7 Jan 2014, In: Analytical Chemistry. 86, 1, p. 340-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Mysling, S., Kristensen, K. K., Larsson, M., Beigneux, A. P., Gårdsvoll, Henrik, Fong, L. G., Bensadouen, A., Jørgensen, T. J. D., Young, S. G. & Ploug, Michael, 2016, In: eLife. 5, 24 p., e12095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator

    Møller, L. B., Ploug, Michael & Blasi, F., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 493-500 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION

    Ossowski, L., Chaurasia, P., Aguirre-Ghiso Julio, A., Zhou, M. & Ploug, Michael, 30 Sep 2010, IPC No. G06G 7/ 60 A I, Patent No. US2010249184, Priority date 17 Mar 2008, Priority No. US20080531502

    Research output: Patent

  17. Published

    First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Persson, M., Skovgaard, D., Brandt-Larsen, M., Christensen, C., Madsen, J., Nielsen, Carsten Haagen, Røndbjerg, T. T., Klausen, Thomas Levin, Holm, S., Loft, A., Berthelsen, A. K., Ploug, Michael, Pappot, H., Brasso, K., Kroman, Niels Thorndahl, Højgaard, Liselotte & Kjær, Andreas, 2015, In: Theranostics. 5, 12, p. 1303-16 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

    Persson, M., Madsen, J., Østergaard, S., Wessel, Mette Munk, Jørgensen, Jesper Tranekjær, Stræde, Karina, Lehmann, C., Ploug, Michael & Kjær, Andreas, 2012, In: Journal of Nuclear Medicine. 53, 1, p. 138-45 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers

    Persson, M., Madsen, J., Østergaard, S., Ploug, Michael & Kjær, Andreas, May 2012, In: Nuclear Medicine and Biology. 39, 4, p. 560-569 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Improved PET Imaging of uPAR expression using new Cu-64-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies

    Persson, M., Hosseini, M., Madsen, J., Jørgensen, T. J. D., Jensen, Knud Jørgen, Kjær, Andreas & Ploug, Michael, 2013, In: Theranostics. 3, 9, p. 618-632 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

    Persson, M., Stræde, Karina, Rasmussen, P., Brandt-Larsen, M., Madsen, J., Ploug, Michael & Kjær, Andreas, 4 Aug 2014, In: Molecular Pharmaceutics. 11, 8, p. 2796–2806 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

    Persson, M., Rasmussen, P., Madsen, J., Ploug, Michael & Kjær, Andreas, Oct 2012, In: Nuclear Medicine and Biology. 39, 7, p. 962-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. uPA binding sites on domain 2+3 on uPAR and antibodies reactive therewith

    Pessara, U., Weidle, U., Koenig, B., Kohnert, U., Bartke, I., Dano, K., Ploug, Michael & Ellis, V., 10 Jan 1996, IPC No. C12R 1/ 91 A N, Patent No. EP0691350, Priority date 8 Jul 1994, Priority No. DK19940000831

    Research output: Patent

  24. Published

    IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS

    Piironen, T., Hoeyer-Hansen, G., Bruenner, N., Ploug, Michael, List, K., Laursen, B., Danoe, K., Liljas, H., Haese, A., Hartwig, H., Toernblom, M. & Gustafsson, O., 18 Nov 2004, IPC No. G06F 19/ 20 A N, Patent No. WO2004099780, Priority date 6 May 2003, Priority No. DK20030000676

    Research output: Patent

  25. Published

    Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor

    Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Multimerization of GPIHBP1 and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1's Ly6 Domain

    Plengpanich, W., Young, S. G., Khovidhunkit, W., Bensadoun, A., Karnman, H., Ploug, Michael, Gardsvoll, H., Leung, C. S., Adeyo, O., Larsson, M., Muanpetch, S., Charoen, S., Fong, L. G., Niramitmahapanya, S. & Beigneux, A. P., 11 Jul 2014, In: The Journal of Biological Chemistry. 289, p. 19491-19499

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

    Plesner, T., Ploug, Michael, Ellis, V., Rønne, E., Høyer-Hansen, G., Wittrup, M., Pedersen, T. L., Tscherning, T., Danø, K. & Hansen, N. E., 1 Feb 1994, In: Blood. 83, 3, p. 808-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR

    Plesner, T., Behrendt, Niels & Ploug, Michael, 1997, In: Stem Cells. 15, 6, p. 398-408 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  29. In situ alkylation of cysteine residues in a hydrophobic membrane protein immobilized on polyvinylidene difluoride membranes by electroblotting prior to microsequence and amino acid analysis

    Ploug, Michael, Stoffer, B. B. & Jensen, A. L., Mar 1992, In: Electrophoresis. 13, 3, p. 148-53 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells

    Ploug, Michael, Rahbek-Nielsen, H., Nielsen, P. F., Roepstorff, P. & Dano, K., 29 May 1998, In: The Journal of Biological Chemistry. 273, 22, p. 13933-43 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins

    Ploug, Michael, Kjalke, M., Rønne, E., Weidle, U., Høyer-Hansen, G. & Danø, K., 15 Aug 1993, In: The Journal of Biological Chemistry. 268, 23, p. 17539-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

    Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly of a composite ligand-binding site

    Ploug, Michael, 24 Nov 1998, In: Biochemistry. 37, 47, p. 16494-505 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria

    Ploug, Michael, Eriksen, J., Plesner, T., Hansen, N. E. & Danø, K., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 397-404 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

    Ploug, Michael, Rønne, E., Behrendt, Niels, Jensen, A. L., Blasi, F. & Danø, K., 25 Jan 1991, In: The Journal of Biological Chemistry. 266, 3, p. 1926-33 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria

    Ploug, Michael, Plesner, T., Rønne, E., Ellis, V., Høyer-Hansen, G., Hansen, N. E. & Danø, K., 15 Mar 1992, In: Blood. 79, 6, p. 1447-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

    Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  38. Published

    Hemolytic plate assay for quantification of active human complement component C3 using methylamine-treated plasma as complement source

    Ploug, Michael, Jessen, T. E., Welinder, K. G. & Barkholt, V., 1 May 1985, In: Analytical Biochemistry. 146, 2, p. 411-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction

    Ploug, Michael, Rahbek-Nielsen, H., Ellis, V., Roepstorff, P. & Danø, K., 3 Oct 1995, In: Biochemistry. 34, 39, p. 12524-34 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

    Ploug, Michael & Ellis, V., 1 Aug 1994, In: FEBS Letters. 349, 2, p. 163-8 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor

    Ploug, Michael, Ellis, V. & Danø, K., 2 Aug 1994, In: Biochemistry. 33, 30, p. 8991-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3

    Ploug, Michael, Jensen, Asger Lundorff & Barkholt, V., 15 Aug 1989, In: Analytical Biochemistry. 181, 1, p. 33-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator

    Ploug, Michael, Behrendt, Niels, Løber, D. & Danø, K., Jul 1991, In: Seminars in Thrombosis and Hemostasis. 17, 3, p. 183-93 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  44. Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation

    Ploug, Michael, Østergaard, S., Hansen, L. B. L., Holm, A. & Danø, K., 17 Mar 1998, In: Biochemistry. 37, 11, p. 3612-22 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Peptide antagonists of the human urokinase receptor and method for selecting them

    Ploug, Michael, Oestergaard, S., Holst-Hansen, C., Stephens, R., Danoe, K. & Holm, A., 11 Apr 2006, IPC No. A61K 38/ 00 A N, Patent No. US7026282, Priority date 1 Jul 1999, Priority No. WO1999DK00377

    Research output: Patent

  46. Published

    Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist

    Ploug, Michael, 2013, In: Theranostics. 3, 7, p. 467-76 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    ANGPTL4: a new mode in the regulation of intravascular lipolysis

    Ploug, Michael, 2022, In: Current Opinion in Lipidology. 33, 2, p. 112-119

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Stepping up the tension in uPAR-mediated signaling by integrins

    Ploug, Michael, 2015

    Research output: Other contribution › Net publication - Internet publication › Research

  49. Published

    Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor

    Ploug, Michael, 2003, In: Current Pharmaceutical Design. 9, 19, p. 1499-528 30 p.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    The PCNA interaction motifs revisited: thinking outside the PIP-box

    Prestel, Andreas, Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, Olaf, Willemoës, Martin, Ploug, Michael, Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    The urokinase receptor as a potential target in cancer therapy

    Romer, J., Nielsen, B. S. & Ploug, Michael, 2004, In: Current Pharmaceutical Design. 10, 19, p. 2359-76 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  52. Published

    Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor

    Rønne, Elsebeth, Behrendt, Niels, Ellis, V., Ploug, Michael, Danø, K. & Høyer-Hansen, G., 19 Aug 1991, In: FEBS Letters. 288, 1-2, p. 233-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay

    Rønne, Elsebeth, Behrendt, Niels, Ploug, Michael, Nielsen, H. J., Wöllisch, E., Weidle, U., Danø, K. & Høyer-Hansen, G., 3 Jan 1994, In: Journal of Immunological Methods. 167, 1-2, p. 91-101 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling

    Solberg, H., Ploug, Michael, Høyer-Hansen, G., Nielsen, B. S. & Lund, L. R., Feb 2001, In: Journal of Histochemistry and Cytochemistry. 49, 2, p. 237-46 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator

    Solberg, H., Løber, D., Eriksen, J., Ploug, Michael, Rønne, E., Behrendt, Niels, Danø, K. & Høyer-Hansen, G., 15 Apr 1992, In: European Journal of Biochemistry. 205, 2, p. 451-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

    Song, W., Beigneux, A. P., Winther, A. M. L., Kristensen, K. K., Grønnemose, A. L., Yang, Y., Tu, Y., Munguia, P., Morales, J., Jung, H., De Jong, P. J., Jung, C. J., Miyashita, K., Kimura, T., Nakajima, K., Murakami, M., Birrane, G., Jiang, H., Tontonoz, P., Ploug, M. & 2 others, Fong, L. G. & Young, S. G., 2022, In: Journal of Clinical Investigation. 132, 5, 15 p., e157500.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing

    Song, W., Beigneux, A. P., Weston, T. A., Chen, K., Yang, Y., Nguyen, L. P., Guagliardo, P., Jung, H., Tran, A. P., Tu, Y., Tran, C., Birrane, G., Miyashita, K., Nakajima, K., Murakami, M., Tontonoz, P., Jiang, H., Ploug, Michael, Fong, L. G. & Young, S. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 44, 12 p., e2313825120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

    Song, W., Yang, Y., Heizer, P., Tu, Y., Weston, T. A., Kim, J. R., Munguia, P., Jung, H., Fong, J. L. C., Tran, C., Ploug, Michael, Beigneux, A. P., Young, S. G. & Fong, L. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, 11 p., e2219833120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

    Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    CL-11 circulates in serum as functionally distinct isoforms

    Sutta, A., Leemans, N. N., Ploug, Michael, Rosbjerg, A., del Agua Villa, C., Pérez-Alós, L., Cyranka, L., Vincek, A. S., de Garay, T., Rivera, K. & Bayarri-Olmos, R., 2024, In: FASEB Journal. 38, 5, 17 p., e23543.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer

    Thurison, T., Almholt, K., Gårdsvoll, Henrik, Ploug, Michael, Høyer-Hansen, G. & Lund, I. K., 25 Mar 2015, In: Molecular Carcinogenesis.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer

    Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

    Trelle, M. B., Hirschberg, D., Jansson, A., Ploug, Michael, Roepstorff, P., Andreasen, P. A. & Jørgensen, Thomas, 16 Oct 2012, In: Biochemistry. 51, 41, p. 8256-66 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection

    Xu, D., Bum-Erdene, K., Leth, Julie Maja, Ghozayel, M. K., Ploug, Michael & Meroueh, S. O., 2020, In: ChemMedChem. 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Crystal structure of the urokinase receptor in a ligand-free form

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  67. Published

    Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen

    Yang, Y., Beigneux, A. P., Song, W., Nguyen, L. P., Jung, H., Tu, Y., Weston, T. A., Tran, C. M., Xie, K., Yu, R. G., Tran, A. P., Miyashita, K., Nakajima, K., Murakami, M., Chen, Y. Q., Zhen, E. Y., Kim, J. R., Kim, P. H., Birrane, G., Tontonoz, P. & 4 others, Ploug, Michael, Konrad, R. J., Fong, L. G. & Young, S. G., 2023, In: Journal of Clinical Investigation. 133, 23, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

    Young, S. G., Fong, L. G., Beigneux, A. P., Allan, C. M., He, C., Jiang, H., Nakajima, K., Meiyappan, M., Birrane, G. & Ploug, Michael, 2019, In: Cell Metabolism. 30, 1, p. 51-65 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  69. Published

    A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism

    Young, S. G., Song, W., Yang, Y., Birrane, G., Jiang, H., Beigneux, A. P., Ploug, Michael & Fong, L. G., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, 12 p., e2211136119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Stabilizing a Flexible Interdomain Hinge Region Harboring the SMB Binding Site Drives uPAR into Its Closed Conformation

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Mar 2015, In: Journal of Molecular Biology. 427, 6B, p. 1389-1403 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Dec 2015, In: Data in Brief. 5, p. 107-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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