Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- Published
Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda
Adeyo, O., Oberer, M., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2015, In: British Journal of Dermatology. 173, 4, p. 1066-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A lipoprotein lipase (LPL)-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1
Allan, C. M., Larsson, M., Hu, X., He, C., Jung, R. S., Mapar, A., Voss, C., Miyashita, K., Machida, T., Murakami, M., Nakajima, K., Bensadoun, A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2016, In: Journal of Lipid Research. 57, 10, p. 1889-1898Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries
Allan, C. M., Larsson, M., Jung, R. S., Ploug, Michael, Bensadoun, A., Beigneux, A. P., Fong, L. G. & Young, S. G., Jan 2017, In: Journal of Lipid Research. 58, 1, p. 216-225Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma
Alpízar-Alpízar, W., Lærum, O. D., Christensen, I. J., Ovrebo, K., Skarstein, A., Høyer-Hansen, G., Ploug, Michael & Illemann, M., Aug 2016, In: Journal of Histochemistry and Cytochemistry. 64, 8, p. 483-94 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis
Alpízar-Alpízar, W., Skindersoe, M. E., Rasmussen, L., Kriegbaum, M. C., Christensen, I. J., Lund, I. K., Illemann, M., Laerum, O. D., Krogfelt, K. A., Andersen, L. P. & Ploug, Michael, 2020, In: Microorganisms. 8, 7, 1019.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteasernes veje og vildveje
Andreasen, P., Kjaer, A., Persson, M. & Ploug, Michael, 2011, In: Aktuel Naturvidenskab. 6, p. 24-27Research output: Contribution to journal › Review › Research
- Published
Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies
Ashraf, A. P., Miyashita, K., Nakajima, K., Murakami, M., Hegele, R. A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Clinical Lipidology. 14, 2, p. 197-200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody
Axelsen, T. V., Holm, A., Birkelund, S., Christiansen, G., Ploug, Michael & Holm, I. E., Jul 2009, In: Molecular Immunology. 46, 11-12, p. 2267-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry
Bache, N., Rand, Kasper Dyrberg, Roepstorff, P., Ploug, Michael & Jørgensen, T., 2008, In: Journal of The American Society for Mass Spectrometry. 19, 12, p. 1719-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains
Bager, R., Kristensen, T. K., Jensen, J., Szczur, A., Christensen, A., Andersen, L., Johansen, J. S., Larsen, N., Baatrup, E., Huang, M., Ploug, Michael & Andreasen, P. A., 2012, In: The Journal of Biological Chemistry. 287, 33, p. 27526-27536 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular receptor for urokinase-type plasminogen activator: protein structure
Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Localization and functional significance of a polymorphic determinant in the third component of human complement
Behrendt, Niels, Hansen, Ole, Ploug, Michael, Barkholt, V. & Koch, C., Oct 1987, In: Molecular Immunology. 24, 10, p. 1097-103 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants
Behrendt, Niels, Rønne, Elsebeth, Ploug, Michael, Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E. & Danø, K., 15 Apr 1990, In: The Journal of Biological Chemistry. 265, 11, p. 6453-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
Beigneux, A. P., Miyashita, K., Ploug, M., Blom, J. D., Ai, M., Linton, M. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J. & 5 others, , 27 Apr 2017, In: New England Journal of Medicine. 376, 17, p. 1647-1658 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipoprotein lipase is active as a monomer
Beigneux, A. P., Allan, C. M., Sandoval, N. P., Cho, G. W., Heizer, P. J., Jung, R. S., Stanhope, K. L., Havel, P. J., Birrane, G., Meiyappan, M., Gill, J. E., Murakami, M., Miyashita, K., Nakajima, K., Ploug, Michael, Fong, L. G. & Young, S. G., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6319-6328 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding
Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Birrane, G., Beigneux, A. P., Dwyer, B., Strack-Logue, B., Kristensen, Kristian Kølby, Francone, O. L., Fong, L. G., Mertens, H. D. T., Pan, C. Q., Ploug, Michael, Young, S. G. & Meiyappan, M., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1723-1732 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The urokinase receptor and regulation of cell surface plasminogen activation
Blasi, F., Cubellis, M. V., Masucci, M. T., Møller, L. B., Olson, D. P., Pedersen, N., Behrendt, Niels, Ellis, V., Ploug, Michael, Rønne, E. & Danø, K., 1990, In: Cell Differentation and Development. 32, 3, p. 247-54Research output: Contribution to journal › Journal article › Research
- Published
Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements
Blouse, G. E., Dupont, D. M., Schar, C. R., Jensen, J. K., Minor, K. H., Anagli, J. Y., Gårdsvoll, Henrik, Ploug, Michael, Peterson, C. B. & Andreasen, P. A., 3 Mar 2009, In: Biochemistry. 48, 8, p. 1723-35 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism
Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Administration of Recombinant Soluble Urokinase Receptor Per Se Is Not Sufficient to Induce Podocyte Alterations and Proteinuria in Mice
Cathelin, D., Placier, S., Ploug, Michael, Verpont, M., Vandermeersch, S., Luque, Y., Hertig, A., Rondeau, E. & Mesnard, L., 2014, In: Journal of the American Society of Nephrology. 25, 8, p. 1662-1668 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Origin and diversification of the plasminogen activation system among chordates
Chana-Muñoz, A., Jendroszek, A., Sønnichsen, M., Wang, T., Ploug, Michael, Jensen, J. K., Andreasen, P. A., Bendixen, C. & Panitz, F., 2019, In: BMC Evolutionary Biology. 19, 1, p. 1-17 17 p., 27.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth
Chaurasia, P., Aguirre-Ghiso, J., Liang, O. D., Gardsvoll, H., Ploug, Michael & Ossowski, L., 26 May 2006, In: The Journal of Biological Chemistry. 281, 21, p. 14852-63 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor
Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase-type plasminogen activator receptor
Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109Research output: Patent
- Published
Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052Research output: Patent
- Published
Plasminogen activation and cancer
Danø, K., Behrendt, N., Hoyer-Hansen, G., Johnsen, M., Lund, L. R., Ploug, Michael & Nielsen, J. R., 2005, In: Thrombosis and Haemostasis. 93, 4, p. 676-681 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion
Danø, K., Behrendt, Niels, Brünner, N., Ellis, V., Ploug, Michael & Oyke, C., 1994, In: Fibrinolysis. 8, Supplement 1, p. 189-203Research output: Contribution to journal › Review › Research › peer-review
- Published
Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
Dupont, D. M., Thuesen, C. K., Bøtkjær, K. A., Behrens, M. A., Dam, K., Sørensen, H. P., Pedersen, J., Ploug, Michael, Jensen, J. K. & Andreasen, P. A., 2015, In: PLOS ONE. 10, 4, 22 p., e0119207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPIHBP1 autoantibody syndrome during interferon β1a treatment
Eguchi, J., Miyashita, K., Fukamachi, I., Nakajima, K., Murakami, M., Kawahara, Y., Yamashita, T., Ohta, Y., Abe, K., Nakatsuka, A., Mino, M., Takase, S., Okazaki, H., Hegele, R. A., Ploug, Michael, Hu, X., Wada, J., Young, S. G. & Beigneux, A. P., 2019, In: Journal of Clinical Lipidology. 13, 1, p. 62-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gene expression and function of the cellular receptor for uPA (uPAR)
Ellis, V., Ploug, Michael, Plesner, T. & Danø, K., 1996, Fibrinolysis in Disease. Glas-Greenwalt, P. (ed.). CRC Press, p. 30-42Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
GPIHBP1 and Plasma Triglyceride Metabolism
Fong, L. G., Young, S. G., Beigneux, A. P., Bensadoun, A., Oberer, M., Jiang, H. & Ploug, Michael, Jul 2016, In: Trends in Endocrinology and Metabolism. 27, 7, p. 455-69 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut
Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction
GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis
Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor
Gårdsvoll, Henrik, Hansen, L. V., Jørgensen, Thomas & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 384-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region
Gårdsvoll, Henrik & Ploug, Michael, 4 May 2007, In: The Journal of Biological Chemistry. 282, 18, p. 13561-72 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia
Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor
Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking
Gårdsvoll, Henrik, Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, Thomas & Ploug, Michael, 14 Jul 2006, In: The Journal of Biological Chemistry. 281, 28, p. 19260-72 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells
Hansen, L., Larsen, E. K. U., Nielsen, E. H., Iversen, F. H., Liu, Z., Thomsen, K. S., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, Michael & Kjems, J., 7 Sep 2013, In: Nanoscale. 5, 17, p. 8192-201 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma
Hansen, L. V., Laerum, O. D., Illemann, M., Nielsen, B. S. & Ploug, Michael, 15 Feb 2008, In: International Journal of Cancer. Supplement. 122, 4, p. 734-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor
Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer
Hansen, L. V., Skov, B. G., Ploug, Michael & Pappot, Helle, Nov 2007, In: Lung Cancer. 58, 2, p. 260-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes
He, C., Weston, T. A., Jung, R. S., Heizer, P., Larsson, M., Hu, X., Allan, C. M., Tontonoz, P., Reue, K., Beigneux, A. P., Ploug, Michael, Holme, A., Kilburn, M., Guagliardo, P., Ford, D. A., Fong, L. G., Young, S. G. & Jiang, H., 1 May 2018, In: Cell Metabolism. 27, 5, p. 1055-1066.e3 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monoclonal Antibodies That Bind to the Ly6 Domain of GPIHBP1 Abolish the Binding of LPL
Hu, X., Sleeman, M. W., Miyashita, K., Linton, M. F., Allan, C. M., He, C., Larsson, M., Tu, Y., Sandoval, N. P., Jung, R. S., Mapar, A., Machida, T., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Jan 2017, In: Journal of Lipid Research. 58, p. 208-215 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
Most downloads
-
218
downloads
Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
207
downloads
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
180
downloads
IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
Research output: Contribution to journal › Journal article › Research › peer-review
Published