Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- 2004
- Published
Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry
Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS
Piironen, T., Hoeyer-Hansen, G., Bruenner, N., Ploug, Michael, List, K., Laursen, B., Danoe, K., Liljas, H., Haese, A., Hartwig, H., Toernblom, M. & Gustafsson, O., 18 Nov 2004, IPC No. G06F 19/ 20 A N, Patent No. WO2004099780, Priority date 6 May 2003, Priority No. DK20030000676Research output: Patent
- Published
Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor
Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor
Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor as a potential target in cancer therapy
Romer, J., Nielsen, B. S. & Ploug, Michael, 2004, In: Current Pharmaceutical Design. 10, 19, p. 2359-76 18 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
- Published
Urokinase-type plasminogen activator receptor
Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109Research output: Patent
- Published
Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor
Ploug, Michael, 2003, In: Current Pharmaceutical Design. 9, 19, p. 1499-528 30 p.Research output: Contribution to journal › Review › Research › peer-review
- 2002
Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy
Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2001
Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation
Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling
Solberg, H., Ploug, Michael, Høyer-Hansen, G., Nielsen, B. S. & Lund, L. R., Feb 2001, In: Journal of Histochemistry and Cytochemistry. 49, 2, p. 237-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice
List, K., Jensen, O. N., Bugge, T. H., Lund, L. R., Ploug, Michael, Danø, K. & Behrendt, Niels, 25 Jan 2000, In: Biochemistry. 39, 3, p. 508-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis
Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052Research output: Patent
- 1998
Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly of a composite ligand-binding site
Ploug, Michael, 24 Nov 1998, In: Biochemistry. 37, 47, p. 16494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells
Ploug, Michael, Rahbek-Nielsen, H., Nielsen, P. F., Roepstorff, P. & Dano, K., 29 May 1998, In: The Journal of Biological Chemistry. 273, 22, p. 13933-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation
Ploug, Michael, Østergaard, S., Hansen, L. B. L., Holm, A. & Danø, K., 17 Mar 1998, In: Biochemistry. 37, 11, p. 3612-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction
Høyer-Hansen, G., Behrendt, Niels, Ploug, Michael, Danø, K. & Preissner, K. T., 22 Dec 1997, In: FEBS Letters. 420, 1, p. 79-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction
GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cell-surface acceleration of urokinase-catalyzed receptor cleavage
Høyer-Hansen, G., Ploug, Michael, Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jan 1997, In: European Journal of Biochemistry. 243, 1-2, p. 21-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR
Plesner, T., Behrendt, Niels & Ploug, Michael, 1997, In: Stem Cells. 15, 6, p. 398-408 11 p.Research output: Contribution to journal › Review › Research › peer-review
- 1996
uPA binding sites on domain 2+3 on uPAR and antibodies reactive therewith
Pessara, U., Weidle, U., Koenig, B., Kohnert, U., Bartke, I., Dano, K., Ploug, Michael & Ellis, V., 10 Jan 1996, IPC No. C12R 1/ 91 A N, Patent No. EP0691350, Priority date 8 Jul 1994, Priority No. DK19940000831Research output: Patent
Gene expression and function of the cellular receptor for uPA (uPAR)
Ellis, V., Ploug, Michael, Plesner, T. & Danø, K., 1996, Fibrinolysis in Disease. Glas-Greenwalt, P. (ed.). CRC Press, p. 30-42Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 1995
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction
Ploug, Michael, Rahbek-Nielsen, H., Ellis, V., Roepstorff, P. & Danø, K., 3 Oct 1995, In: Biochemistry. 34, 39, p. 12524-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor
Ploug, Michael, Ellis, V. & Danø, K., 2 Aug 1994, In: Biochemistry. 33, 30, p. 8991-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
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