Michael Ploug

Michael Ploug

Group leader

ORCID: 0000-0003-2215-4265

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  1. Published

    Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda

    Adeyo, O., Oberer, M., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2015, In: British Journal of Dermatology. 173, 4, p. 1066-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A lipoprotein lipase (LPL)-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1

    Allan, C. M., Larsson, M., Hu, X., He, C., Jung, R. S., Mapar, A., Voss, C., Miyashita, K., Machida, T., Murakami, M., Nakajima, K., Bensadoun, A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2016, In: Journal of Lipid Research. 57, 10, p. 1889-1898

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries

    Allan, C. M., Larsson, M., Jung, R. S., Ploug, Michael, Bensadoun, A., Beigneux, A. P., Fong, L. G. & Young, S. G., Jan 2017, In: Journal of Lipid Research. 58, 1, p. 216-225

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma

    Alpízar-Alpízar, W., Lærum, O. D., Christensen, I. J., Ovrebo, K., Skarstein, A., Høyer-Hansen, G., Ploug, Michael & Illemann, M., Aug 2016, In: Journal of Histochemistry and Cytochemistry. 64, 8, p. 483-94 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis

    Alpízar-Alpízar, W., Skindersoe, M. E., Rasmussen, L., Kriegbaum, M. C., Christensen, I. J., Lund, I. K., Illemann, M., Laerum, O. D., Krogfelt, K. A., Andersen, L. P. & Ploug, Michael, 2020, In: Microorganisms. 8, 7, 1019.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Proteasernes veje og vildveje

    Andreasen, P., Kjaer, A., Persson, M. & Ploug, Michael, 2011, In: Aktuel Naturvidenskab. 6, p. 24-27

    Research output: Contribution to journal › Review › Research

  7. Published

    Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies

    Ashraf, A. P., Miyashita, K., Nakajima, K., Murakami, M., Hegele, R. A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Clinical Lipidology. 14, 2, p. 197-200

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody

    Axelsen, T. V., Holm, A., Birkelund, S., Christiansen, G., Ploug, Michael & Holm, I. E., Jul 2009, In: Molecular Immunology. 46, 11-12, p. 2267-73 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry

    Bache, N., Rand, Kasper Dyrberg, Roepstorff, P., Ploug, Michael & Jørgensen, T., 2008, In: Journal of The American Society for Mass Spectrometry. 19, 12, p. 1719-25 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains

    Bager, R., Kristensen, T. K., Jensen, J., Szczur, A., Christensen, A., Andersen, L., Johansen, J. S., Larsen, N., Baatrup, E., Huang, M., Ploug, Michael & Andreasen, P. A., 2012, In: The Journal of Biological Chemistry. 287, 33, p. 27526-27536 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Cellular receptor for urokinase-type plasminogen activator: protein structure

    Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  12. Published

    Localization and functional significance of a polymorphic determinant in the third component of human complement

    Behrendt, Niels, Hansen, Ole, Ploug, Michael, Barkholt, V. & Koch, C., Oct 1987, In: Molecular Immunology. 24, 10, p. 1097-103 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants

    Behrendt, Niels, Rønne, Elsebeth, Ploug, Michael, Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E. & Danø, K., 15 Apr 1990, In: The Journal of Biological Chemistry. 265, 11, p. 6453-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

    Beigneux, A. P., Miyashita, K., Ploug, M., Blom, J. D., Ai, M., Linton, M. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J. & 5 others, Moulin, P., Charrière, S., Fong, L. G., Nakajima, K. & Young, S. G., 27 Apr 2017, In: New England Journal of Medicine. 376, 17, p. 1647-1658 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Lipoprotein lipase is active as a monomer

    Beigneux, A. P., Allan, C. M., Sandoval, N. P., Cho, G. W., Heizer, P. J., Jung, R. S., Stanhope, K. L., Havel, P. J., Birrane, G., Meiyappan, M., Gill, J. E., Murakami, M., Miyashita, K., Nakajima, K., Ploug, Michael, Fong, L. G. & Young, S. G., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6319-6328 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding

    Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis

    Birrane, G., Beigneux, A. P., Dwyer, B., Strack-Logue, B., Kristensen, Kristian Kølby, Francone, O. L., Fong, L. G., Mertens, H. D. T., Pan, C. Q., Ploug, Michael, Young, S. G. & Meiyappan, M., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1723-1732 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. The urokinase receptor and regulation of cell surface plasminogen activation

    Blasi, F., Cubellis, M. V., Masucci, M. T., Møller, L. B., Olson, D. P., Pedersen, N., Behrendt, Niels, Ellis, V., Ploug, Michael, Rønne, E. & Danø, K., 1990, In: Cell Differentation and Development. 32, 3, p. 247-54

    Research output: Contribution to journal › Journal article › Research

  19. Published

    Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements

    Blouse, G. E., Dupont, D. M., Schar, C. R., Jensen, J. K., Minor, K. H., Anagli, J. Y., Gårdsvoll, Henrik, Ploug, Michael, Peterson, C. B. & Andreasen, P. A., 3 Mar 2009, In: Biochemistry. 48, 8, p. 1723-35 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism

    Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Administration of Recombinant Soluble Urokinase Receptor Per Se Is Not Sufficient to Induce Podocyte Alterations and Proteinuria in Mice

    Cathelin, D., Placier, S., Ploug, Michael, Verpont, M., Vandermeersch, S., Luque, Y., Hertig, A., Rondeau, E. & Mesnard, L., 2014, In: Journal of the American Society of Nephrology. 25, 8, p. 1662-1668 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Origin and diversification of the plasminogen activation system among chordates

    Chana-Muñoz, A., Jendroszek, A., Sønnichsen, M., Wang, T., Ploug, Michael, Jensen, J. K., Andreasen, P. A., Bendixen, C. & Panitz, F., 2019, In: BMC Evolutionary Biology. 19, 1, p. 1-17 17 p., 27.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

    Chaurasia, P., Aguirre-Ghiso, J., Liang, O. D., Gardsvoll, H., Ploug, Michael & Ossowski, L., 26 May 2006, In: The Journal of Biological Chemistry. 281, 21, p. 14852-63 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor

    Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

    Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Urokinase-type plasminogen activator receptor

    Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, Patthy, L., 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109

    Research output: Patent

  27. Published

    Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

    Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, Patthy, L., 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052

    Research output: Patent

  28. Published

    Plasminogen activation and cancer

    Danø, K., Behrendt, N., Hoyer-Hansen, G., Johnsen, M., Lund, L. R., Ploug, Michael & Nielsen, J. R., 2005, In: Thrombosis and Haemostasis. 93, 4, p. 676-681 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion

    Danø, K., Behrendt, Niels, Brünner, N., Ellis, V., Ploug, Michael & Oyke, C., 1994, In: Fibrinolysis. 8, Supplement 1, p. 189-203

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

    Dupont, D. M., Thuesen, C. K., Bøtkjær, K. A., Behrens, M. A., Dam, K., Sørensen, H. P., Pedersen, J., Ploug, Michael, Jensen, J. K. & Andreasen, P. A., 2015, In: PLOS ONE. 10, 4, 22 p., e0119207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    GPIHBP1 autoantibody syndrome during interferon β1a treatment

    Eguchi, J., Miyashita, K., Fukamachi, I., Nakajima, K., Murakami, M., Kawahara, Y., Yamashita, T., Ohta, Y., Abe, K., Nakatsuka, A., Mino, M., Takase, S., Okazaki, H., Hegele, R. A., Ploug, Michael, Hu, X., Wada, J., Young, S. G. & Beigneux, A. P., 2019, In: Journal of Clinical Lipidology. 13, 1, p. 62-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Gene expression and function of the cellular receptor for uPA (uPAR)

    Ellis, V., Ploug, Michael, Plesner, T. & Danø, K., 1996, Fibrinolysis in Disease. Glas-Greenwalt, P. (ed.). CRC Press, p. 30-42

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  33. Published

    GPIHBP1 and Plasma Triglyceride Metabolism

    Fong, L. G., Young, S. G., Beigneux, A. P., Bensadoun, A., Oberer, M., Jiang, H. & Ploug, Michael, Jul 2016, In: Trends in Endocrinology and Metabolism. 27, 7, p. 455-69 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

    Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction

    GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis

    Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor

    Gårdsvoll, Henrik, Hansen, L. V., Jørgensen, Thomas & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 384-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region

    Gårdsvoll, Henrik & Ploug, Michael, 4 May 2007, In: The Journal of Biological Chemistry. 282, 18, p. 13561-72 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction

    Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia

    Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor

    Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

    Gårdsvoll, Henrik, Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, Thomas & Ploug, Michael, 14 Jul 2006, In: The Journal of Biological Chemistry. 281, 28, p. 19260-72 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites

    Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    Hansen, L., Larsen, E. K. U., Nielsen, E. H., Iversen, F. H., Liu, Z., Thomsen, K. S., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, Michael & Kjems, J., 7 Sep 2013, In: Nanoscale. 5, 17, p. 8192-201 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma

    Hansen, L. V., Laerum, O. D., Illemann, M., Nielsen, B. S. & Ploug, Michael, 15 Feb 2008, In: International Journal of Cancer. Supplement. 122, 4, p. 734-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor

    Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer

    Hansen, L. V., Skov, B. G., Ploug, Michael & Pappot, Helle, Nov 2007, In: Lung Cancer. 58, 2, p. 260-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes

    He, C., Weston, T. A., Jung, R. S., Heizer, P., Larsson, M., Hu, X., Allan, C. M., Tontonoz, P., Reue, K., Beigneux, A. P., Ploug, Michael, Holme, A., Kilburn, M., Guagliardo, P., Ford, D. A., Fong, L. G., Young, S. G. & Jiang, H., 1 May 2018, In: Cell Metabolism. 27, 5, p. 1055-1066.e3 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

    Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Monoclonal Antibodies That Bind to the Ly6 Domain of GPIHBP1 Abolish the Binding of LPL

    Hu, X., Sleeman, M. W., Miyashita, K., Linton, M. F., Allan, C. M., He, C., Larsson, M., Tu, Y., Sandoval, N. P., Jung, R. S., Mapar, A., Machida, T., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Jan 2017, In: Journal of Lipid Research. 58, p. 208-215 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 33978213