Khodosevich Group

We aim to address the key questions for our understanding of brain function “how such complex organ as the brain is build up during development?” and “what goes wrong in neurodevelopmental disorders?”.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Selected publications

Experimental papers

Batiuk M#, Tyler T#, Dragicevic K, Mei S, Rydbirk R, Petukhov V, Deviatiiarov R, Sedmak D, Frank E, Feher V, Habek N, Hu Q, Igolkina A, Roszik L, Pfisterer U, Garcia-Gonzalez D, Petanjek Z, Adorjan I, Kharchenko P, Khodosevich K (2022) Upper cortical layer–driven network impairment in schizophrenia. Sci Adv 8, doi:10.1126/SCIADV.ABN8367

Malwade S, Gasthaus J, Bellardita C, Andelic M, Moric B, Korshunova I, Kiehn O, Vasistha NA, Khodosevich K. (2022) Identification of vulnerable interneuron subtypes in 15q13.3 microdeletion syndrome using single-cell transcriptomics. Biol Psychiatry, 91(8): 727-739

Pfisterer #, Demharter S.#, Petukhov V.#, Meichsner J.#, Thompson J., Batiuk M., Asenjo Martinez A., Vasistha N., Thakur A., Mikkelsen J., Adorjan I., Pinborg L., Pers T., von Engelhardt J., Kharchenko P., Khodosevich K. (2020) Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis. Nat Commun, 11(1):1-19

Vasistha N.#, Pardo-Navarro M.#, Gasthaus J., Weijers D., Müller M., García-González D., Malwade S., Korshunova I., Pfisterer U., von Engelhardt J., Hougaard K., Khodosevich K. (2019) Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific mannerMol Psychiatry, 10.1038/s41380-019-0539-5

Sanz Morello B., Pfisterer U., Hansen N., Demharter S., Thakur A., Fujii K., Levitskiy S., Montalant A., Korshunova I., Mammen P., Kamenski P., Noguchi S., Aldana Garcia B., Hougaard K., Perrier J., Khodosevich K. (2020) Unique isoform in oxidative phosphorylation machinery supports the function of fast-spiking neurons. EMBO J, 39(18):e105759

Computational papers

Petukhov V#, Igolkina A#, Rydbirk R, Mei S, Christoffersen L, Khodosevich K#, Kharchenko P# (2022). Case-control analysis of single-cell RNA-seq studies. bioRxiv 2022.03.15.484475.

Petukhov V, Xu R, Soldatov RA, Cadinu P, Khodosevich K, Moffitt J, Kharchenko P. (2021) Cell segmentation in imaging-based spatial transcriptomics. Nat Biotech, 40(3): 345-354

Barkas N.#, Petukhov V.#, Nikolaeva D., Lozinsky Y., Demharter S., Khodosevich K., Kharchenko PV. (2019). Joint analysis of heterogeneous single-cell RNA-seq dataset collections. Nat Methods, 2019 Jul 15. doi: 10.1038/s41592-019-0466-z.

View all publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

In the media

Forskere på KU afslører de specifikke neuron-fejl bag skizofreni

19.10.2022 by Ingeniøren (story also brought in Dagens Medicin and on bric.ku.dk)

Et bestemt gen kobles til autisme, ADHD, skizofreni og andre diagnoser

02.11.2021 by Videnskab.dk

New video: How to build a healthy brain.

Study identifies brain cells most affected by epilepsy and new targets for their treatment

07.10.2020 by Faculty of Health and Medical Sciences

BRIC researchers discover role of metabolism gene in brain dysfunction

04.08.2020 by BRIC

How are psychiatric disorders linked to infections during pregnancy?

30.10.2019 by Faculty of Health and Medical Sciences

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