Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- 1985
- Published
Hemolytic plate assay for quantification of active human complement component C3 using methylamine-treated plasma as complement source
Ploug, Michael, Jessen, T. E., Welinder, K. G. & Barkholt, V., 1 May 1985, In: Analytical Biochemistry. 146, 2, p. 411-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
Localization and functional significance of a polymorphic determinant in the third component of human complement
Behrendt, Niels, Hansen, Ole, Ploug, Michael, Barkholt, V. & Koch, C., Oct 1987, In: Molecular Immunology. 24, 10, p. 1097-103 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1988
- Published
Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure
Jessen, T. E., Faarvang, K. L. & Ploug, Michael, 28 Mar 1988, In: FEBS Letters. 230, 1-2, p. 195-200 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1989
Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3
Ploug, Michael, Jensen, Asger Lundorff & Barkholt, V., 15 Aug 1989, In: Analytical Biochemistry. 181, 1, p. 33-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
The urokinase receptor and regulation of cell surface plasminogen activation
Blasi, F., Cubellis, M. V., Masucci, M. T., Møller, L. B., Olson, D. P., Pedersen, N., Behrendt, Niels, Ellis, V., Ploug, Michael, Rønne, E. & Danø, K., 1990, In: Cell Differentation and Development. 32, 3, p. 247-54Research output: Contribution to journal › Journal article › Research
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants
Behrendt, Niels, Rønne, Elsebeth, Ploug, Michael, Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E. & Danø, K., 15 Apr 1990, In: The Journal of Biological Chemistry. 265, 11, p. 6453-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
Ploug, Michael, Rønne, E., Behrendt, Niels, Jensen, A. L., Blasi, F. & Danø, K., 25 Jan 1991, In: The Journal of Biological Chemistry. 266, 3, p. 1926-33 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator
Ploug, Michael, Behrendt, Niels, Løber, D. & Danø, K., Jul 1991, In: Seminars in Thrombosis and Hemostasis. 17, 3, p. 183-93 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor
Rønne, Elsebeth, Behrendt, Niels, Ellis, V., Ploug, Michael, Danø, K. & Høyer-Hansen, G., 19 Aug 1991, In: FEBS Letters. 288, 1-2, p. 233-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
In situ alkylation of cysteine residues in a hydrophobic membrane protein immobilized on polyvinylidene difluoride membranes by electroblotting prior to microsequence and amino acid analysis
Ploug, Michael, Stoffer, B. B. & Jensen, A. L., Mar 1992, In: Electrophoresis. 13, 3, p. 148-53 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria
Ploug, Michael, Plesner, T., Rønne, E., Ellis, V., Høyer-Hansen, G., Hansen, N. E. & Danø, K., 15 Mar 1992, In: Blood. 79, 6, p. 1447-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator
Solberg, H., Løber, D., Eriksen, J., Ploug, Michael, Rønne, E., Behrendt, Niels, Danø, K. & Høyer-Hansen, G., 15 Apr 1992, In: European Journal of Biochemistry. 205, 2, p. 451-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria
Ploug, Michael, Eriksen, J., Plesner, T., Hansen, N. E. & Danø, K., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 397-404 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator
Møller, L. B., Ploug, Michael & Blasi, F., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 493-500 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain
Høyer-Hansen, G., Rønne, E., Solberg, H., Behrendt, Niels, Ploug, Michael, Lund, L. R., Ellis, V. & Danø, K., 5 Sep 1992, In: The Journal of Biological Chemistry. 267, 25, p. 18224-18229 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
Cellular receptor for urokinase-type plasminogen activator: protein structure
Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins
Ploug, Michael, Kjalke, M., Rønne, E., Weidle, U., Høyer-Hansen, G. & Danø, K., 15 Aug 1993, In: The Journal of Biological Chemistry. 268, 23, p. 17539-46 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion
Danø, K., Behrendt, Niels, Brünner, N., Ellis, V., Ploug, Michael & Oyke, C., 1994, In: Fibrinolysis. 8, Supplement 1, p. 189-203Research output: Contribution to journal › Review › Research › peer-review
- Published
Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay
Rønne, Elsebeth, Behrendt, Niels, Ploug, Michael, Nielsen, H. J., Wöllisch, E., Weidle, U., Danø, K. & Høyer-Hansen, G., 3 Jan 1994, In: Journal of Immunological Methods. 167, 1-2, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils
Plesner, T., Ploug, Michael, Ellis, V., Rønne, E., Høyer-Hansen, G., Wittrup, M., Pedersen, T. L., Tscherning, T., Danø, K. & Hansen, N. E., 1 Feb 1994, In: Blood. 83, 3, p. 808-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins
Ploug, Michael & Ellis, V., 1 Aug 1994, In: FEBS Letters. 349, 2, p. 163-8 6 p.Research output: Contribution to journal › Review › Research › peer-review
Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor
Ploug, Michael, Ellis, V. & Danø, K., 2 Aug 1994, In: Biochemistry. 33, 30, p. 8991-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction
Ploug, Michael, Rahbek-Nielsen, H., Ellis, V., Roepstorff, P. & Danø, K., 3 Oct 1995, In: Biochemistry. 34, 39, p. 12524-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
Gene expression and function of the cellular receptor for uPA (uPAR)
Ellis, V., Ploug, Michael, Plesner, T. & Danø, K., 1996, Fibrinolysis in Disease. Glas-Greenwalt, P. (ed.). CRC Press, p. 30-42Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
uPA binding sites on domain 2+3 on uPAR and antibodies reactive therewith
Pessara, U., Weidle, U., Koenig, B., Kohnert, U., Bartke, I., Dano, K., Ploug, Michael & Ellis, V., 10 Jan 1996, IPC No. C12R 1/ 91 A N, Patent No. EP0691350, Priority date 8 Jul 1994, Priority No. DK19940000831Research output: Patent
- 1997
Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR
Plesner, T., Behrendt, Niels & Ploug, Michael, 1997, In: Stem Cells. 15, 6, p. 398-408 11 p.Research output: Contribution to journal › Review › Research › peer-review
Cell-surface acceleration of urokinase-catalyzed receptor cleavage
Høyer-Hansen, G., Ploug, Michael, Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jan 1997, In: European Journal of Biochemistry. 243, 1-2, p. 21-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction
GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction
Høyer-Hansen, G., Behrendt, Niels, Ploug, Michael, Danø, K. & Preissner, K. T., 22 Dec 1997, In: FEBS Letters. 420, 1, p. 79-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation
Ploug, Michael, Østergaard, S., Hansen, L. B. L., Holm, A. & Danø, K., 17 Mar 1998, In: Biochemistry. 37, 11, p. 3612-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells
Ploug, Michael, Rahbek-Nielsen, H., Nielsen, P. F., Roepstorff, P. & Dano, K., 29 May 1998, In: The Journal of Biological Chemistry. 273, 22, p. 13933-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly of a composite ligand-binding site
Ploug, Michael, 24 Nov 1998, In: Biochemistry. 37, 47, p. 16494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052Research output: Patent
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis
Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice
List, K., Jensen, O. N., Bugge, T. H., Lund, L. R., Ploug, Michael, Danø, K. & Behrendt, Niels, 25 Jan 2000, In: Biochemistry. 39, 3, p. 508-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling
Solberg, H., Ploug, Michael, Høyer-Hansen, G., Nielsen, B. S. & Lund, L. R., Feb 2001, In: Journal of Histochemistry and Cytochemistry. 49, 2, p. 237-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation
Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy
Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
- Published
Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor
Ploug, Michael, 2003, In: Current Pharmaceutical Design. 9, 19, p. 1499-528 30 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Urokinase-type plasminogen activator receptor
Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109Research output: Patent
- 2004
- Published
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor as a potential target in cancer therapy
Romer, J., Nielsen, B. S. & Ploug, Michael, 2004, In: Current Pharmaceutical Design. 10, 19, p. 2359-76 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor
Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor
Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS
Piironen, T., Hoeyer-Hansen, G., Bruenner, N., Ploug, Michael, List, K., Laursen, B., Danoe, K., Liljas, H., Haese, A., Hartwig, H., Toernblom, M. & Gustafsson, O., 18 Nov 2004, IPC No. G06F 19/ 20 A N, Patent No. WO2004099780, Priority date 6 May 2003, Priority No. DK20030000676Research output: Patent
- Published
Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry
Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Plasminogen activation and cancer
Danø, K., Behrendt, N., Hoyer-Hansen, G., Johnsen, M., Lund, L. R., Ploug, Michael & Nielsen, J. R., 2005, In: Thrombosis and Haemostasis. 93, 4, p. 676-681 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation
Jørgensen, Thomas, Gårdsvoll, Henrik, Ploug, Michael & Roepstorff, P., 2 Mar 2005, In: Journal of the American Chemical Society. 127, 8, p. 2785-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides
Jørgensen, Thomas, Bache, N., Roepstorff, P., Gårdsvoll, Henrik & Ploug, Michael, Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 1910-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
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