Michael Ploug

Michael Ploug

Group leader

ORCID: 0000-0003-2215-4265

Publication year:
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  1. 1985
  2. Published

    Hemolytic plate assay for quantification of active human complement component C3 using methylamine-treated plasma as complement source

    Ploug, Michael, Jessen, T. E., Welinder, K. G. & Barkholt, V., 1 May 1985, In: Analytical Biochemistry. 146, 2, p. 411-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 1987
  4. Published

    Localization and functional significance of a polymorphic determinant in the third component of human complement

    Behrendt, Niels, Hansen, Ole, Ploug, Michael, Barkholt, V. & Koch, C., Oct 1987, In: Molecular Immunology. 24, 10, p. 1097-103 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 1988
  6. Published

    Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure

    Jessen, T. E., Faarvang, K. L. & Ploug, Michael, 28 Mar 1988, In: FEBS Letters. 230, 1-2, p. 195-200 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 1989

  8. Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3

    Ploug, Michael, Jensen, Asger Lundorff & Barkholt, V., 15 Aug 1989, In: Analytical Biochemistry. 181, 1, p. 33-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1990

  10. The urokinase receptor and regulation of cell surface plasminogen activation

    Blasi, F., Cubellis, M. V., Masucci, M. T., Møller, L. B., Olson, D. P., Pedersen, N., Behrendt, Niels, Ellis, V., Ploug, Michael, Rønne, E. & Danø, K., 1990, In: Cell Differentation and Development. 32, 3, p. 247-54

    Research output: Contribution to journal › Journal article › Research

  11. The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants

    Behrendt, Niels, Rønne, Elsebeth, Ploug, Michael, Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E. & Danø, K., 15 Apr 1990, In: The Journal of Biological Chemistry. 265, 11, p. 6453-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 1991

  13. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

    Ploug, Michael, Rønne, E., Behrendt, Niels, Jensen, A. L., Blasi, F. & Danø, K., 25 Jan 1991, In: The Journal of Biological Chemistry. 266, 3, p. 1926-33 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator

    Ploug, Michael, Behrendt, Niels, Løber, D. & Danø, K., Jul 1991, In: Seminars in Thrombosis and Hemostasis. 17, 3, p. 183-93 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor

    Rønne, Elsebeth, Behrendt, Niels, Ellis, V., Ploug, Michael, Danø, K. & Høyer-Hansen, G., 19 Aug 1991, In: FEBS Letters. 288, 1-2, p. 233-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 1992

  17. In situ alkylation of cysteine residues in a hydrophobic membrane protein immobilized on polyvinylidene difluoride membranes by electroblotting prior to microsequence and amino acid analysis

    Ploug, Michael, Stoffer, B. B. & Jensen, A. L., Mar 1992, In: Electrophoresis. 13, 3, p. 148-53 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria

    Ploug, Michael, Plesner, T., Rønne, E., Ellis, V., Høyer-Hansen, G., Hansen, N. E. & Danø, K., 15 Mar 1992, In: Blood. 79, 6, p. 1447-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator

    Solberg, H., Løber, D., Eriksen, J., Ploug, Michael, Rønne, E., Behrendt, Niels, Danø, K. & Høyer-Hansen, G., 15 Apr 1992, In: European Journal of Biochemistry. 205, 2, p. 451-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria

    Ploug, Michael, Eriksen, J., Plesner, T., Hansen, N. E. & Danø, K., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 397-404 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator

    Møller, L. B., Ploug, Michael & Blasi, F., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 493-500 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

    Høyer-Hansen, G., Rønne, E., Solberg, H., Behrendt, Niels, Ploug, Michael, Lund, L. R., Ellis, V. & Danø, K., 5 Sep 1992, In: The Journal of Biological Chemistry. 267, 25, p. 18224-18229 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 1993
  24. Published

    Cellular receptor for urokinase-type plasminogen activator: protein structure

    Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  25. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins

    Ploug, Michael, Kjalke, M., Rønne, E., Weidle, U., Høyer-Hansen, G. & Danø, K., 15 Aug 1993, In: The Journal of Biological Chemistry. 268, 23, p. 17539-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 1994

  27. The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion

    Danø, K., Behrendt, Niels, Brünner, N., Ellis, V., Ploug, Michael & Oyke, C., 1994, In: Fibrinolysis. 8, Supplement 1, p. 189-203

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay

    Rønne, Elsebeth, Behrendt, Niels, Ploug, Michael, Nielsen, H. J., Wöllisch, E., Weidle, U., Danø, K. & Høyer-Hansen, G., 3 Jan 1994, In: Journal of Immunological Methods. 167, 1-2, p. 91-101 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

    Plesner, T., Ploug, Michael, Ellis, V., Rønne, E., Høyer-Hansen, G., Wittrup, M., Pedersen, T. L., Tscherning, T., Danø, K. & Hansen, N. E., 1 Feb 1994, In: Blood. 83, 3, p. 808-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

    Ploug, Michael & Ellis, V., 1 Aug 1994, In: FEBS Letters. 349, 2, p. 163-8 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  31. Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor

    Ploug, Michael, Ellis, V. & Danø, K., 2 Aug 1994, In: Biochemistry. 33, 30, p. 8991-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 1995

  33. Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction

    Ploug, Michael, Rahbek-Nielsen, H., Ellis, V., Roepstorff, P. & Danø, K., 3 Oct 1995, In: Biochemistry. 34, 39, p. 12524-34 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 1996

  35. Gene expression and function of the cellular receptor for uPA (uPAR)

    Ellis, V., Ploug, Michael, Plesner, T. & Danø, K., 1996, Fibrinolysis in Disease. Glas-Greenwalt, P. (ed.). CRC Press, p. 30-42

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  36. uPA binding sites on domain 2+3 on uPAR and antibodies reactive therewith

    Pessara, U., Weidle, U., Koenig, B., Kohnert, U., Bartke, I., Dano, K., Ploug, Michael & Ellis, V., 10 Jan 1996, IPC No. C12R 1/ 91 A N, Patent No. EP0691350, Priority date 8 Jul 1994, Priority No. DK19940000831

    Research output: Patent

  37. 1997

  38. Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR

    Plesner, T., Behrendt, Niels & Ploug, Michael, 1997, In: Stem Cells. 15, 6, p. 398-408 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  39. Cell-surface acceleration of urokinase-catalyzed receptor cleavage

    Høyer-Hansen, G., Ploug, Michael, Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jan 1997, In: European Journal of Biochemistry. 243, 1-2, p. 21-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction

    GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

    Høyer-Hansen, G., Behrendt, Niels, Ploug, Michael, Danø, K. & Preissner, K. T., 22 Dec 1997, In: FEBS Letters. 420, 1, p. 79-85 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 1998

  43. Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation

    Ploug, Michael, Østergaard, S., Hansen, L. B. L., Holm, A. & Danø, K., 17 Mar 1998, In: Biochemistry. 37, 11, p. 3612-22 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells

    Ploug, Michael, Rahbek-Nielsen, H., Nielsen, P. F., Roepstorff, P. & Dano, K., 29 May 1998, In: The Journal of Biological Chemistry. 273, 22, p. 13933-43 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly of a composite ligand-binding site

    Ploug, Michael, 24 Nov 1998, In: Biochemistry. 37, 47, p. 16494-505 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 1999
  47. Published

    Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

    Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, Patthy, L., 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052

    Research output: Patent

  48. Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis

    Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2000

  50. Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice

    List, K., Jensen, O. N., Bugge, T. H., Lund, L. R., Ploug, Michael, Danø, K. & Behrendt, Niels, 25 Jan 2000, In: Biochemistry. 39, 3, p. 508-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2001

  52. The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling

    Solberg, H., Ploug, Michael, Høyer-Hansen, G., Nielsen, B. S. & Lund, L. R., Feb 2001, In: Journal of Histochemistry and Cytochemistry. 49, 2, p. 237-46 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

    Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2002

  55. Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

    Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  56. 2003
  57. Published

    Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor

    Ploug, Michael, 2003, In: Current Pharmaceutical Design. 9, 19, p. 1499-528 30 p.

    Research output: Contribution to journal › Review › Research › peer-review

  58. Published

    Urokinase-type plasminogen activator receptor

    Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, Patthy, L., 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109

    Research output: Patent

  59. 2004
  60. Published

    Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites

    Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    The urokinase receptor as a potential target in cancer therapy

    Romer, J., Nielsen, B. S. & Ploug, Michael, 2004, In: Current Pharmaceutical Design. 10, 19, p. 2359-76 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  62. Published

    Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor

    Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor

    Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS

    Piironen, T., Hoeyer-Hansen, G., Bruenner, N., Ploug, Michael, List, K., Laursen, B., Danoe, K., Liljas, H., Haese, A., Hartwig, H., Toernblom, M. & Gustafsson, O., 18 Nov 2004, IPC No. G06F 19/ 20 A N, Patent No. WO2004099780, Priority date 6 May 2003, Priority No. DK20030000676

    Research output: Patent

  65. Published

    Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry

    Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. 2005
  67. Published

    Plasminogen activation and cancer

    Danø, K., Behrendt, N., Hoyer-Hansen, G., Johnsen, M., Lund, L. R., Ploug, Michael & Nielsen, J. R., 2005, In: Thrombosis and Haemostasis. 93, 4, p. 676-681 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation

    Jørgensen, Thomas, Gårdsvoll, Henrik, Ploug, Michael & Roepstorff, P., 2 Mar 2005, In: Journal of the American Chemical Society. 127, 8, p. 2785-93 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

    Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides

    Jørgensen, Thomas, Bache, N., Roepstorff, P., Gårdsvoll, Henrik & Ploug, Michael, Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 1910-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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